Placental H3K27me3 establishes female resilience to prenatal insults

Placental H3K27me3 establishes female resilience to prenatal insults

Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene e...

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Autores principales: Bridget M. Nugent, Carly M. O’Donnell, C. Neill Epperson, Tracy L. Bale
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d2b40a39c962402aa3b1a3c295491f24
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spelling oai:doaj.org-article:d2b40a39c962402aa3b1a3c295491f242021-12-02T15:34:15ZPlacental H3K27me3 establishes female resilience to prenatal insults10.1038/s41467-018-04992-12041-1723https://doaj.org/article/d2b40a39c962402aa3b1a3c295491f242018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04992-1https://doaj.org/toc/2041-1723Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.Bridget M. NugentCarly M. O’DonnellC. Neill EppersonTracy L. BaleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bridget M. Nugent
Carly M. O’Donnell
C. Neill Epperson
Tracy L. Bale
Placental H3K27me3 establishes female resilience to prenatal insults
description Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.
format article
author Bridget M. Nugent
Carly M. O’Donnell
C. Neill Epperson
Tracy L. Bale
author_facet Bridget M. Nugent
Carly M. O’Donnell
C. Neill Epperson
Tracy L. Bale
author_sort Bridget M. Nugent
title Placental H3K27me3 establishes female resilience to prenatal insults
title_short Placental H3K27me3 establishes female resilience to prenatal insults
title_full Placental H3K27me3 establishes female resilience to prenatal insults
title_fullStr Placental H3K27me3 establishes female resilience to prenatal insults
title_full_unstemmed Placental H3K27me3 establishes female resilience to prenatal insults
title_sort placental h3k27me3 establishes female resilience to prenatal insults
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d2b40a39c962402aa3b1a3c295491f24
work_keys_str_mv AT bridgetmnugent placentalh3k27me3establishesfemaleresiliencetoprenatalinsults
AT carlymodonnell placentalh3k27me3establishesfemaleresiliencetoprenatalinsults
AT cneillepperson placentalh3k27me3establishesfemaleresiliencetoprenatalinsults
AT tracylbale placentalh3k27me3establishesfemaleresiliencetoprenatalinsults
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