A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke

Abstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absenc...

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Autores principales:	Mark E. Pepin, Eyad Saca, Soo Y. Kwon, Jori May
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adalimumab microangiopathy thromboembolic stroke thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d2b42c09d15f4379bcf46e961c1ce451
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spelling	oai:doaj.org-article:d2b42c09d15f4379bcf46e961c1ce4512021-12-02T07:55:56ZA case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke2050-090410.1002/ccr3.4850https://doaj.org/article/d2b42c09d15f4379bcf46e961c1ce4512021-10-01T00:00:00Zhttps://doi.org/10.1002/ccr3.4850https://doaj.org/toc/2050-0904Abstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absence of appropriate treatment. In the current report, we describe a case of immune‐mediated TTP (iTTP) in a 62‐year‐old man manifesting as longstanding thrombocytopenia, recurrent cardioembolic strokes, and valvular thrombogenesis over a period of 3 years. We provide correlative evidence to support the potential contribution of adalimumab, a TNFα inhibitor, to the development of iTTP. We offer several educational insights regarding the identification of atypical presentations of iTTP owing to the longstanding disease course and numerous clinical comorbidities seen in this patient.Mark E. PepinEyad SacaSoo Y. KwonJori MayWileyarticleadalimumabmicroangiopathythromboembolic strokethrombotic thrombocytopenic purpuraMedicineRMedicine (General)R5-920ENClinical Case Reports, Vol 9, Iss 10, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adalimumab microangiopathy thromboembolic stroke thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920
spellingShingle	adalimumab microangiopathy thromboembolic stroke thrombotic thrombocytopenic purpura Medicine R Medicine (General) R5-920 Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
description	Abstract Prompt recognition and treatment for thrombotic thrombocytopenic purpura (TTP) are critical to prevent the irreversible manifestations of this rare and quickly fatal hematologic disorder. Untreated TTP is typically a rapid‐onset disease with mortality exceeding 90% within days in the absence of appropriate treatment. In the current report, we describe a case of immune‐mediated TTP (iTTP) in a 62‐year‐old man manifesting as longstanding thrombocytopenia, recurrent cardioembolic strokes, and valvular thrombogenesis over a period of 3 years. We provide correlative evidence to support the potential contribution of adalimumab, a TNFα inhibitor, to the development of iTTP. We offer several educational insights regarding the identification of atypical presentations of iTTP owing to the longstanding disease course and numerous clinical comorbidities seen in this patient.
format	article
author	Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May
author_facet	Mark E. Pepin Eyad Saca Soo Y. Kwon Jori May
author_sort	Mark E. Pepin
title	A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
title_short	A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
title_full	A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
title_fullStr	A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
title_full_unstemmed	A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
title_sort	case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d2b42c09d15f4379bcf46e961c1ce451
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A case of “smoldering” immune‐mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke

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