Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beigi...

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Autores principales: Takahiro Seki, Kayoko Hosaka, Sharon Lim, Carina Fischer, Jennifer Honek, Yunlong Yang, Patrik Andersson, Masaki Nakamura, Erik Näslund, Seppo Ylä-Herttuala, Meili Sun, Hideki Iwamoto, Xuri Li, Yizhi Liu, Nilesh J. Samani, Yihai Cao
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/d2b7dcc14440407294f031a92cd4d4a9
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spelling oai:doaj.org-article:d2b7dcc14440407294f031a92cd4d4a92021-12-02T16:57:02ZEndothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat10.1038/ncomms121522041-1723https://doaj.org/article/d2b7dcc14440407294f031a92cd4d4a92016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12152https://doaj.org/toc/2041-1723Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging.Takahiro SekiKayoko HosakaSharon LimCarina FischerJennifer HonekYunlong YangPatrik AnderssonMasaki NakamuraErik NäslundSeppo Ylä-HerttualaMeili SunHideki IwamotoXuri LiYizhi LiuNilesh J. SamaniYihai CaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takahiro Seki
Kayoko Hosaka
Sharon Lim
Carina Fischer
Jennifer Honek
Yunlong Yang
Patrik Andersson
Masaki Nakamura
Erik Näslund
Seppo Ylä-Herttuala
Meili Sun
Hideki Iwamoto
Xuri Li
Yizhi Liu
Nilesh J. Samani
Yihai Cao
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
description Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging.
format article
author Takahiro Seki
Kayoko Hosaka
Sharon Lim
Carina Fischer
Jennifer Honek
Yunlong Yang
Patrik Andersson
Masaki Nakamura
Erik Näslund
Seppo Ylä-Herttuala
Meili Sun
Hideki Iwamoto
Xuri Li
Yizhi Liu
Nilesh J. Samani
Yihai Cao
author_facet Takahiro Seki
Kayoko Hosaka
Sharon Lim
Carina Fischer
Jennifer Honek
Yunlong Yang
Patrik Andersson
Masaki Nakamura
Erik Näslund
Seppo Ylä-Herttuala
Meili Sun
Hideki Iwamoto
Xuri Li
Yizhi Liu
Nilesh J. Samani
Yihai Cao
author_sort Takahiro Seki
title Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
title_short Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
title_full Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
title_fullStr Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
title_full_unstemmed Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
title_sort endothelial pdgf-cc regulates angiogenesis-dependent thermogenesis in beige fat
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/d2b7dcc14440407294f031a92cd4d4a9
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