Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model

Background: Hypertension is a major risk factor for cardiovascular disease (CVD), which is the number one cause of global mortality. The potential use of natural products to alleviate high blood pressure has been demonstrated to exert a cardioprotective effect. Centella asiatica (L.) Urb. belongs to...

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Autores principales:	Mohd Khairulanwar Bunaim, Yusof Kamisah, Mohd Noor Mohd Mustazil, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Norliza Muhammad
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Centella asiatica cardiac damage hypertension nitro-l-arginine methyl ester nitric oxide Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d2baa0a00e5b44898a8cc082f0d36950
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spelling	oai:doaj.org-article:d2baa0a00e5b44898a8cc082f0d369502021-12-03T06:56:43ZCentella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model1663-981210.3389/fphar.2021.742562https://doaj.org/article/d2baa0a00e5b44898a8cc082f0d369502021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.742562/fullhttps://doaj.org/toc/1663-9812Background: Hypertension is a major risk factor for cardiovascular disease (CVD), which is the number one cause of global mortality. The potential use of natural products to alleviate high blood pressure has been demonstrated to exert a cardioprotective effect. Centella asiatica (L.) Urb. belongs to the plant family Apiaceae (Umbelliferae). It contains a high amount of triterpenoid and flavonoid that have antioxidant properties and are involved in the renin-angiotensin-aldosterone system which is an important hormonal system for blood pressure regulation.Objective: This study aimed to investigate the effects of C. asiatica ethanolic extract on blood pressure and heart in a hypertensive rat model, which was induced using oral N(G)-nitro-l-arginine methyl ester (l-NAME).Methods: Male Sprague-Dawley rats were divided into five groups and were given different treatments for 8 weeks. Group 1 only received deionized water. Groups 2, 4, and 5 were given l-NAME (40 mg/kg, orally). Groups 4 and 5 concurrently received C. asiatica extract (500 mg/kg, orally) and captopril (5 mg/kg, orally), respectively. Group 3 only received C. asiatica extract (500 mg/kg body weight, orally). Systolic blood pressure (SBP) was measured at weeks 0, 4, and 8, while serum nitric oxide (NO) was measured at weeks 0 and 8. At necropsy, cardiac and aortic malondialdehyde (MDA) contents, cardiac angiotensin-converting enzyme (ACE) activity, and serum level of brain natriuretic peptide (BNP) were measured.Results: After 8 weeks, the administrations of C. asiatica extract and captopril showed significant (p < 0.05) effects on preventing the elevation of SBP, reducing the serum nitric oxide level, as well as increasing the cardiac and aortic MDA content, cardiac ACE activity, and serum brain natriuretic peptide level.Conclusion:C. asiatica extract can prevent the development of hypertension and cardiac damage induced by l-NAME, and these effects were comparable to captopril.Mohd Khairulanwar BunaimMohd Khairulanwar BunaimYusof KamisahMohd Noor Mohd MustazilJapar Sidik Fadhlullah ZuhairAbdul Hamid JulianaNorliza MuhammadFrontiers Media S.A.articleCentella asiaticacardiac damagehypertensionnitro-l-arginine methyl esternitric oxideTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Centella asiatica cardiac damage hypertension nitro-l-arginine methyl ester nitric oxide Therapeutics. Pharmacology RM1-950
spellingShingle	Centella asiatica cardiac damage hypertension nitro-l-arginine methyl ester nitric oxide Therapeutics. Pharmacology RM1-950 Mohd Khairulanwar Bunaim Mohd Khairulanwar Bunaim Yusof Kamisah Mohd Noor Mohd Mustazil Japar Sidik Fadhlullah Zuhair Abdul Hamid Juliana Norliza Muhammad Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
description	Background: Hypertension is a major risk factor for cardiovascular disease (CVD), which is the number one cause of global mortality. The potential use of natural products to alleviate high blood pressure has been demonstrated to exert a cardioprotective effect. Centella asiatica (L.) Urb. belongs to the plant family Apiaceae (Umbelliferae). It contains a high amount of triterpenoid and flavonoid that have antioxidant properties and are involved in the renin-angiotensin-aldosterone system which is an important hormonal system for blood pressure regulation.Objective: This study aimed to investigate the effects of C. asiatica ethanolic extract on blood pressure and heart in a hypertensive rat model, which was induced using oral N(G)-nitro-l-arginine methyl ester (l-NAME).Methods: Male Sprague-Dawley rats were divided into five groups and were given different treatments for 8 weeks. Group 1 only received deionized water. Groups 2, 4, and 5 were given l-NAME (40 mg/kg, orally). Groups 4 and 5 concurrently received C. asiatica extract (500 mg/kg, orally) and captopril (5 mg/kg, orally), respectively. Group 3 only received C. asiatica extract (500 mg/kg body weight, orally). Systolic blood pressure (SBP) was measured at weeks 0, 4, and 8, while serum nitric oxide (NO) was measured at weeks 0 and 8. At necropsy, cardiac and aortic malondialdehyde (MDA) contents, cardiac angiotensin-converting enzyme (ACE) activity, and serum level of brain natriuretic peptide (BNP) were measured.Results: After 8 weeks, the administrations of C. asiatica extract and captopril showed significant (p < 0.05) effects on preventing the elevation of SBP, reducing the serum nitric oxide level, as well as increasing the cardiac and aortic MDA content, cardiac ACE activity, and serum brain natriuretic peptide level.Conclusion:C. asiatica extract can prevent the development of hypertension and cardiac damage induced by l-NAME, and these effects were comparable to captopril.
format	article
author	Mohd Khairulanwar Bunaim Mohd Khairulanwar Bunaim Yusof Kamisah Mohd Noor Mohd Mustazil Japar Sidik Fadhlullah Zuhair Abdul Hamid Juliana Norliza Muhammad
author_facet	Mohd Khairulanwar Bunaim Mohd Khairulanwar Bunaim Yusof Kamisah Mohd Noor Mohd Mustazil Japar Sidik Fadhlullah Zuhair Abdul Hamid Juliana Norliza Muhammad
author_sort	Mohd Khairulanwar Bunaim
title	Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
title_short	Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
title_full	Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
title_fullStr	Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
title_full_unstemmed	Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model
title_sort	centella asiatica (l.) urb. prevents hypertension and protects the heart in chronic nitric oxide deficiency rat model
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d2baa0a00e5b44898a8cc082f0d36950
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Centella asiatica (L.) Urb. Prevents Hypertension and Protects the Heart in Chronic Nitric Oxide Deficiency Rat Model

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