Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.

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Autores principales:	Pingsu Mao, Jingfan Liu, Zepeng Zhang, Hong Zhang, Haiying Liu, Song Gao, Yikang S. Rong, Yong Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2bac6d7cd1a4e06a3fb1dee8eae9893
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spelling	oai:doaj.org-article:d2bac6d7cd1a4e06a3fb1dee8eae98932021-12-02T15:34:52ZHomologous recombination-dependent repair of telomeric DSBs in proliferating human cells10.1038/ncomms121542041-1723https://doaj.org/article/d2bac6d7cd1a4e06a3fb1dee8eae98932016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12154https://doaj.org/toc/2041-1723Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.Pingsu MaoJingfan LiuZepeng ZhangHong ZhangHaiying LiuSong GaoYikang S. RongYong ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pingsu Mao Jingfan Liu Zepeng Zhang Hong Zhang Haiying Liu Song Gao Yikang S. Rong Yong Zhao Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
description	Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.
format	article
author	Pingsu Mao Jingfan Liu Zepeng Zhang Hong Zhang Haiying Liu Song Gao Yikang S. Rong Yong Zhao
author_facet	Pingsu Mao Jingfan Liu Zepeng Zhang Hong Zhang Haiying Liu Song Gao Yikang S. Rong Yong Zhao
author_sort	Pingsu Mao
title	Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
title_short	Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
title_full	Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
title_fullStr	Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
title_full_unstemmed	Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
title_sort	homologous recombination-dependent repair of telomeric dsbs in proliferating human cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d2bac6d7cd1a4e06a3fb1dee8eae9893
work_keys_str_mv	AT pingsumao homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT jingfanliu homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT zepengzhang homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT hongzhang homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT haiyingliu homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT songgao homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT yikangsrong homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells AT yongzhao homologousrecombinationdependentrepairoftelomericdsbsinproliferatinghumancells
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Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

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