Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.

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Autores principales: Pingsu Mao, Jingfan Liu, Zepeng Zhang, Hong Zhang, Haiying Liu, Song Gao, Yikang S. Rong, Yong Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/d2bac6d7cd1a4e06a3fb1dee8eae9893
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