Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm

Traditional treatment approaches for advanced malignancies have been associated with limited clinical outcomes necessitating the development of novel therapies. However, the ability of radiotherapy to induce pro-immunogenic changes in tumor immune microenvironment can be leveraged when combined with...

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Autor principal:	Umair Mahmood
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	immunomodulation radiotherapy immunotherapy tumor immune microenvironment Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d2bc7c42ec9642d581b32b2e12d565a4
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spelling	oai:doaj.org-article:d2bc7c42ec9642d581b32b2e12d565a42021-11-04T15:51:57ZRadiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm2578-582610.1080/25785826.2021.1997268https://doaj.org/article/d2bc7c42ec9642d581b32b2e12d565a42021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/25785826.2021.1997268https://doaj.org/toc/2578-5826Traditional treatment approaches for advanced malignancies have been associated with limited clinical outcomes necessitating the development of novel therapies. However, the ability of radiotherapy to induce pro-immunogenic changes in tumor immune microenvironment can be leveraged when combined with systemic agents. Radio-immunotherapeutic initiatives employing the use of monoclonal antibodies, genetically engineered T cells, cytokines and virus-vector mediated gene therapies have demonstrated promising potential for the management of various solid malignancies. Future studies incorporating biomarker enrichment strategies and radiobiological variables could pave the way for immune-oncology based personalized medicine approaches to be integrated in standard of care practices for the treatment of challenging clinical populations.Umair MahmoodTaylor & Francis Grouparticleimmunomodulationradiotherapyimmunotherapytumor immune microenvironmentImmunologic diseases. AllergyRC581-607ENImmunological Medicine, Vol 0, Iss 0, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunomodulation radiotherapy immunotherapy tumor immune microenvironment Immunologic diseases. Allergy RC581-607
spellingShingle	immunomodulation radiotherapy immunotherapy tumor immune microenvironment Immunologic diseases. Allergy RC581-607 Umair Mahmood Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
description	Traditional treatment approaches for advanced malignancies have been associated with limited clinical outcomes necessitating the development of novel therapies. However, the ability of radiotherapy to induce pro-immunogenic changes in tumor immune microenvironment can be leveraged when combined with systemic agents. Radio-immunotherapeutic initiatives employing the use of monoclonal antibodies, genetically engineered T cells, cytokines and virus-vector mediated gene therapies have demonstrated promising potential for the management of various solid malignancies. Future studies incorporating biomarker enrichment strategies and radiobiological variables could pave the way for immune-oncology based personalized medicine approaches to be integrated in standard of care practices for the treatment of challenging clinical populations.
format	article
author	Umair Mahmood
author_facet	Umair Mahmood
author_sort	Umair Mahmood
title	Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
title_short	Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
title_full	Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
title_fullStr	Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
title_full_unstemmed	Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
title_sort	radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d2bc7c42ec9642d581b32b2e12d565a4
work_keys_str_mv	AT umairmahmood radiotherapydrivenimmunomodulationofthetumormicroenvironmentanditsimpactonclinicaloutcomesapromisingnewtreatmentparadigm
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Radiotherapy driven immunomodulation of the tumor microenvironment and its impact on clinical outcomes: a promising new treatment paradigm

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