Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.

Increased blue light exposure has become a matter of concern as it has a range of detrimental effects, but the mechanisms remain unclear. Mitochondria absorb short wavelength light but have a specific absorbance at 420nm at the lower end of the human visual range. This 420nm absorption is probably d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jaimie Hoh Kam, Chris Hogg, Robert Fosbury, Harpreet Shinhmar, Glen Jeffery
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2bd2e0264ca489ebb04570e71eae2ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2bd2e0264ca489ebb04570e71eae2ec
record_format	dspace
spelling	oai:doaj.org-article:d2bd2e0264ca489ebb04570e71eae2ec2021-12-02T20:08:31ZMitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.1932-620310.1371/journal.pone.0257149https://doaj.org/article/d2bd2e0264ca489ebb04570e71eae2ec2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257149https://doaj.org/toc/1932-6203Increased blue light exposure has become a matter of concern as it has a range of detrimental effects, but the mechanisms remain unclear. Mitochondria absorb short wavelength light but have a specific absorbance at 420nm at the lower end of the human visual range. This 420nm absorption is probably due to the presence of porphyrin. We examine the impact of 420nm exposure on drosophila melanogaster mitochondria and its impact on fly mobility. Daily 15 mins exposures for a week significantly reduced mitochondrial complex activities and increased mitochondrial inner membrane permeability, which is a key metric of mitochondrial health. Adenosine triphosphate (ATP) levels were not significantly reduced and mobility was unchanged. There are multiple options for energy/time exposure combinations, but we then applied single 420nm exposure of 3h to increase the probability of an effect on ATP and mobility, and both were significantly reduced. ATP and mitochondrial membrane permeability recovered and over corrected at 72h post exposure. However, despite this, normal mobility did not return. Hence, the effect of short wavelengths on mitochondrial function is to reduce complex activity and increasing membrane permeability, but light exposure to reduce ATP and to translate into reduced mobility needs to be sustained.Jaimie Hoh KamChris HoggRobert FosburyHarpreet ShinhmarGlen JefferyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaimie Hoh Kam Chris Hogg Robert Fosbury Harpreet Shinhmar Glen Jeffery Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
description	Increased blue light exposure has become a matter of concern as it has a range of detrimental effects, but the mechanisms remain unclear. Mitochondria absorb short wavelength light but have a specific absorbance at 420nm at the lower end of the human visual range. This 420nm absorption is probably due to the presence of porphyrin. We examine the impact of 420nm exposure on drosophila melanogaster mitochondria and its impact on fly mobility. Daily 15 mins exposures for a week significantly reduced mitochondrial complex activities and increased mitochondrial inner membrane permeability, which is a key metric of mitochondrial health. Adenosine triphosphate (ATP) levels were not significantly reduced and mobility was unchanged. There are multiple options for energy/time exposure combinations, but we then applied single 420nm exposure of 3h to increase the probability of an effect on ATP and mobility, and both were significantly reduced. ATP and mitochondrial membrane permeability recovered and over corrected at 72h post exposure. However, despite this, normal mobility did not return. Hence, the effect of short wavelengths on mitochondrial function is to reduce complex activity and increasing membrane permeability, but light exposure to reduce ATP and to translate into reduced mobility needs to be sustained.
format	article
author	Jaimie Hoh Kam Chris Hogg Robert Fosbury Harpreet Shinhmar Glen Jeffery
author_facet	Jaimie Hoh Kam Chris Hogg Robert Fosbury Harpreet Shinhmar Glen Jeffery
author_sort	Jaimie Hoh Kam
title	Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
title_short	Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
title_full	Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
title_fullStr	Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
title_full_unstemmed	Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
title_sort	mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d2bd2e0264ca489ebb04570e71eae2ec
work_keys_str_mv	AT jaimiehohkam mitochondriaarespecificallyvulnerableto420nmlightindrosophilawhichunderminestheirfunctionandisassociatedwithreducedflymobility AT chrishogg mitochondriaarespecificallyvulnerableto420nmlightindrosophilawhichunderminestheirfunctionandisassociatedwithreducedflymobility AT robertfosbury mitochondriaarespecificallyvulnerableto420nmlightindrosophilawhichunderminestheirfunctionandisassociatedwithreducedflymobility AT harpreetshinhmar mitochondriaarespecificallyvulnerableto420nmlightindrosophilawhichunderminestheirfunctionandisassociatedwithreducedflymobility AT glenjeffery mitochondriaarespecificallyvulnerableto420nmlightindrosophilawhichunderminestheirfunctionandisassociatedwithreducedflymobility
_version_	1718375209780641792

Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility.

Ejemplares similares