Cortisol biosynthesis in the human ocular surface innate immune response.

Cortisol biosynthesis in the human ocular surface innate immune response.

Innate immune responses have a critical role in regulating sight-threatening ocular surface (OcS) inflammation. While glucocorticoids (GCs) are frequently used to limit tissue damage, the role of intracrine GC (cortisol) bioavailability via 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in O...

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Auteurs principaux: Radhika Susarla, Lei Liu, Elizabeth A Walker, Iwona J Bujalska, Jawaher Alsalem, Geraint P Williams, Sreekanth Sreekantam, Angela E Taylor, Mohammad Tallouzi, H Susan Southworth, Philip I Murray, Graham R Wallace, Saaeha Rauz
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/d2bd508f07b346feb6cb34bfdf15e08a
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