Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood

Abstract The Developmental Origins of Health and Disease (DOHaD) framework suggests that early-life experiences affect long-term health outcomes. We tested this hypothesis by estimating the long-run effects of exposure to World War II-related food deprivation during childhood and adolescence on the...

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Autores principales:	Julia Mink, Marie-Christine Boutron-Ruault, Marie-Aline Charles, Olivier Allais, Guy Fagherazzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2bf8de229054400a93d2d2f5953e750
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spelling	oai:doaj.org-article:d2bf8de229054400a93d2d2f5953e7502021-12-02T18:18:07ZAssociations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood10.1038/s41598-020-62576-w2045-2322https://doaj.org/article/d2bf8de229054400a93d2d2f5953e7502020-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-62576-whttps://doaj.org/toc/2045-2322Abstract The Developmental Origins of Health and Disease (DOHaD) framework suggests that early-life experiences affect long-term health outcomes. We tested this hypothesis by estimating the long-run effects of exposure to World War II-related food deprivation during childhood and adolescence on the risk of suffering from hypertension and type 2 diabetes at adulthood for 90,226 women from the French prospective cohort study E3N. We found that the experience of food deprivation during early-life was associated with a higher risk of developing type 2 diabetes (+0.7%, 95% CI: 0.073–1.37%) and hypertension (+2.6%, 95% CI: 0.81–4.45%). Effects were stronger for individuals exposed at younger ages. Exposed individuals also achieved lower levels of education, slept less, and were more frequently smokers than unexposed individuals. These results are compatible with both the latency and the pathway models proposed in the DOHaD framework which theorise the association between early life exposure and adult health through both a direct link and an indirect link where changes in health determinants mediate health outcomes.Julia MinkMarie-Christine Boutron-RuaultMarie-Aline CharlesOlivier AllaisGuy FagherazziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julia Mink Marie-Christine Boutron-Ruault Marie-Aline Charles Olivier Allais Guy Fagherazzi Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
description	Abstract The Developmental Origins of Health and Disease (DOHaD) framework suggests that early-life experiences affect long-term health outcomes. We tested this hypothesis by estimating the long-run effects of exposure to World War II-related food deprivation during childhood and adolescence on the risk of suffering from hypertension and type 2 diabetes at adulthood for 90,226 women from the French prospective cohort study E3N. We found that the experience of food deprivation during early-life was associated with a higher risk of developing type 2 diabetes (+0.7%, 95% CI: 0.073–1.37%) and hypertension (+2.6%, 95% CI: 0.81–4.45%). Effects were stronger for individuals exposed at younger ages. Exposed individuals also achieved lower levels of education, slept less, and were more frequently smokers than unexposed individuals. These results are compatible with both the latency and the pathway models proposed in the DOHaD framework which theorise the association between early life exposure and adult health through both a direct link and an indirect link where changes in health determinants mediate health outcomes.
format	article
author	Julia Mink Marie-Christine Boutron-Ruault Marie-Aline Charles Olivier Allais Guy Fagherazzi
author_facet	Julia Mink Marie-Christine Boutron-Ruault Marie-Aline Charles Olivier Allais Guy Fagherazzi
author_sort	Julia Mink
title	Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
title_short	Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
title_full	Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
title_fullStr	Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
title_full_unstemmed	Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood
title_sort	associations between early-life food deprivation during world war ii and risk of hypertension and type 2 diabetes at adulthood
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d2bf8de229054400a93d2d2f5953e750
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Associations between early-life food deprivation during World War II and risk of hypertension and type 2 diabetes at adulthood

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