FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA

Some features of peripheral bood basophil activation were studied in children with different types of chronic urticaria, in order to specify the sustaining mechanisms of chronic urticaria. This study presents comparative data concerning spontaneous basophil activation, IgE level and Th2 helper cells...

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Autores principales:	N. A. Sinelnikova, N. V. Bychkova, N. M. Kalinina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	chronic urticaria basophils ige cd203c type 2 t-helper cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d2c05059037b4b07b58540a781ba81bb
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spelling	oai:doaj.org-article:d2c05059037b4b07b58540a781ba81bb2021-11-18T08:03:44ZFEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA1563-06252313-741X10.15789/1563-0625-2015-1-39-46https://doaj.org/article/d2c05059037b4b07b58540a781ba81bb2015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/806https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSome features of peripheral bood basophil activation were studied in children with different types of chronic urticaria, in order to specify the sustaining mechanisms of chronic urticaria. This study presents comparative data concerning spontaneous basophil activation, IgE level and Th2 helper cells. We observed forty-seven children with chronic urticaria, seventy children with exacerbated atopic dermatitis with different disease severity, fifteen healthy children without signs of allergy, or pseudo-allergy. High degree of the basophil activation was detected in children with exacerbation of atopic dermatitis (a comparison group), which was different from the groups of healthy children and patients with chronic urticaria. Spontaneous basophile activation was higher in children with chronic urticaria than in healthy children, as influenced by immune and non-immune pathogenetic factors of the disease. A positive pairwise correlation was shown between total IgE level, and Th2 helper cell numbers in peripheral blood in patients with chronic urticaria, thus confirming a Th2 immune shift. The results obtained contribute to our understanding of immune pathology in chronic urticaria.N. A. SinelnikovaN. V. BychkovaN. M. KalininaSPb RAACIarticlechronic urticariabasophilsigecd203ctype 2 t-helper cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 39-46 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic urticaria basophils ige cd203c type 2 t-helper cells Immunologic diseases. Allergy RC581-607
spellingShingle	chronic urticaria basophils ige cd203c type 2 t-helper cells Immunologic diseases. Allergy RC581-607 N. A. Sinelnikova N. V. Bychkova N. M. Kalinina FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
description	Some features of peripheral bood basophil activation were studied in children with different types of chronic urticaria, in order to specify the sustaining mechanisms of chronic urticaria. This study presents comparative data concerning spontaneous basophil activation, IgE level and Th2 helper cells. We observed forty-seven children with chronic urticaria, seventy children with exacerbated atopic dermatitis with different disease severity, fifteen healthy children without signs of allergy, or pseudo-allergy. High degree of the basophil activation was detected in children with exacerbation of atopic dermatitis (a comparison group), which was different from the groups of healthy children and patients with chronic urticaria. Spontaneous basophile activation was higher in children with chronic urticaria than in healthy children, as influenced by immune and non-immune pathogenetic factors of the disease. A positive pairwise correlation was shown between total IgE level, and Th2 helper cell numbers in peripheral blood in patients with chronic urticaria, thus confirming a Th2 immune shift. The results obtained contribute to our understanding of immune pathology in chronic urticaria.
format	article
author	N. A. Sinelnikova N. V. Bychkova N. M. Kalinina
author_facet	N. A. Sinelnikova N. V. Bychkova N. M. Kalinina
author_sort	N. A. Sinelnikova
title	FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
title_short	FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
title_full	FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
title_fullStr	FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
title_full_unstemmed	FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
title_sort	features of immune response and basophil activation in children with chronic urticaria
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/d2c05059037b4b07b58540a781ba81bb
work_keys_str_mv	AT nasinelnikova featuresofimmuneresponseandbasophilactivationinchildrenwithchronicurticaria AT nvbychkova featuresofimmuneresponseandbasophilactivationinchildrenwithchronicurticaria AT nmkalinina featuresofimmuneresponseandbasophilactivationinchildrenwithchronicurticaria
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FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA

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