Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis

The growth factor VEGF is known to regulate vasculogenesis but the downstream pathways activated are unclear. Here, the authors report that Sec14l3, a member of the PITP (phosphatidyl inositol transfer proteins) family regulates the formation of zebrafish vasculature by promoting VEGFR2 endocytic tr...

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Autores principales:	Bo Gong, Zhihao Li, Wanghua Xiao, Guangyuan Li, Shihui Ding, Anming Meng, Shunji Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2c3d3634ea94410b6db140db1268168
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spelling	oai:doaj.org-article:d2c3d3634ea94410b6db140db12681682021-12-02T14:39:42ZSec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis10.1038/s41467-019-09604-02041-1723https://doaj.org/article/d2c3d3634ea94410b6db140db12681682019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09604-0https://doaj.org/toc/2041-1723The growth factor VEGF is known to regulate vasculogenesis but the downstream pathways activated are unclear. Here, the authors report that Sec14l3, a member of the PITP (phosphatidyl inositol transfer proteins) family regulates the formation of zebrafish vasculature by promoting VEGFR2 endocytic trafficking.Bo GongZhihao LiWanghua XiaoGuangyuan LiShihui DingAnming MengShunji JiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Gong Zhihao Li Wanghua Xiao Guangyuan Li Shihui Ding Anming Meng Shunji Jia Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
description	The growth factor VEGF is known to regulate vasculogenesis but the downstream pathways activated are unclear. Here, the authors report that Sec14l3, a member of the PITP (phosphatidyl inositol transfer proteins) family regulates the formation of zebrafish vasculature by promoting VEGFR2 endocytic trafficking.
format	article
author	Bo Gong Zhihao Li Wanghua Xiao Guangyuan Li Shihui Ding Anming Meng Shunji Jia
author_facet	Bo Gong Zhihao Li Wanghua Xiao Guangyuan Li Shihui Ding Anming Meng Shunji Jia
author_sort	Bo Gong
title	Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
title_short	Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
title_full	Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
title_fullStr	Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
title_full_unstemmed	Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis
title_sort	sec14l3 potentiates vegfr2 signaling to regulate zebrafish vasculogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d2c3d3634ea94410b6db140db1268168
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Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis

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