NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity

Abstract The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and p...

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Autores principales:	Alan C. Pilon, Marilia Valli, Alessandra C. Dametto, Meri Emili F. Pinto, Rafael T. Freire, Ian Castro-Gamboa, Adriano D. Andricopulo, Vanderlan S. Bolzani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2c61497adf54582995d23a27a0968b8
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spelling	oai:doaj.org-article:d2c61497adf54582995d23a27a0968b82021-12-02T15:05:48ZNuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity10.1038/s41598-017-07451-x2045-2322https://doaj.org/article/d2c61497adf54582995d23a27a0968b82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07451-xhttps://doaj.org/toc/2045-2322Abstract The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBEDB has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBEDB is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBEDB. We also present a preliminary study on the current profile of the compounds present in Brazilian territory.Alan C. PilonMarilia ValliAlessandra C. DamettoMeri Emili F. PintoRafael T. FreireIan Castro-GamboaAdriano D. AndricopuloVanderlan S. BolzaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alan C. Pilon Marilia Valli Alessandra C. Dametto Meri Emili F. Pinto Rafael T. Freire Ian Castro-Gamboa Adriano D. Andricopulo Vanderlan S. Bolzani NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
description	Abstract The intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBEDB has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBEDB is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBEDB. We also present a preliminary study on the current profile of the compounds present in Brazilian territory.
format	article
author	Alan C. Pilon Marilia Valli Alessandra C. Dametto Meri Emili F. Pinto Rafael T. Freire Ian Castro-Gamboa Adriano D. Andricopulo Vanderlan S. Bolzani
author_facet	Alan C. Pilon Marilia Valli Alessandra C. Dametto Meri Emili F. Pinto Rafael T. Freire Ian Castro-Gamboa Adriano D. Andricopulo Vanderlan S. Bolzani
author_sort	Alan C. Pilon
title	NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
title_short	NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
title_full	NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
title_fullStr	NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
title_full_unstemmed	NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
title_sort	nubbedb: an updated database to uncover chemical and biological information from brazilian biodiversity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2c61497adf54582995d23a27a0968b8
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NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity

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