Destruction mechanisms of ozone over SARS-CoV-2

Abstract In this pandemic SARS-CoV-2 crisis, any attempt to contain and eliminate the virus will also stop its spread and consequently decrease the risk of severe illness and death. While ozone treatment has been suggested as an effective disinfection process, no precise mechanism of action has been...

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Autores principales:	Angila Ataei-Pirkooh, Ali Alavi, Mehran Kianirad, Kowsar Bagherzadeh, Alireza Ghasempour, Omid Pourdakan, Reza Adl, Seyed Jalal Kiani, Mehdi Mirzaei, Bita Mehravi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2c84c5066bd414a9f61eba2628dcfdd
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spelling	oai:doaj.org-article:d2c84c5066bd414a9f61eba2628dcfdd2021-12-02T18:14:22ZDestruction mechanisms of ozone over SARS-CoV-210.1038/s41598-021-97860-w2045-2322https://doaj.org/article/d2c84c5066bd414a9f61eba2628dcfdd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97860-whttps://doaj.org/toc/2045-2322Abstract In this pandemic SARS-CoV-2 crisis, any attempt to contain and eliminate the virus will also stop its spread and consequently decrease the risk of severe illness and death. While ozone treatment has been suggested as an effective disinfection process, no precise mechanism of action has been previously reported. This study aimed to further investigate the effect of ozone treatment on SARS-CoV-2. Therefore, virus collected from nasopharyngeal and oropharyngeal swab and sputum samples from symptomatic patients was exposed to ozone for different exposure times. The virus morphology and structure were monitored and analyzed through Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Atomic Absorption Spectroscopy (AAS), and ATR-FTIR. The obtained results showed that ozone treatment not only unsettles the virus morphology but also alters the virus proteins’ structure and conformation through amino acid disturbance and Zn ion release from the virus non-structural proteins. These results could provide a clearer pathway for virus elimination and therapeutics preparation.Angila Ataei-PirkoohAli AlaviMehran KianiradKowsar BagherzadehAlireza GhasempourOmid PourdakanReza AdlSeyed Jalal KianiMehdi MirzaeiBita MehraviNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angila Ataei-Pirkooh Ali Alavi Mehran Kianirad Kowsar Bagherzadeh Alireza Ghasempour Omid Pourdakan Reza Adl Seyed Jalal Kiani Mehdi Mirzaei Bita Mehravi Destruction mechanisms of ozone over SARS-CoV-2
description	Abstract In this pandemic SARS-CoV-2 crisis, any attempt to contain and eliminate the virus will also stop its spread and consequently decrease the risk of severe illness and death. While ozone treatment has been suggested as an effective disinfection process, no precise mechanism of action has been previously reported. This study aimed to further investigate the effect of ozone treatment on SARS-CoV-2. Therefore, virus collected from nasopharyngeal and oropharyngeal swab and sputum samples from symptomatic patients was exposed to ozone for different exposure times. The virus morphology and structure were monitored and analyzed through Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Atomic Absorption Spectroscopy (AAS), and ATR-FTIR. The obtained results showed that ozone treatment not only unsettles the virus morphology but also alters the virus proteins’ structure and conformation through amino acid disturbance and Zn ion release from the virus non-structural proteins. These results could provide a clearer pathway for virus elimination and therapeutics preparation.
format	article
author	Angila Ataei-Pirkooh Ali Alavi Mehran Kianirad Kowsar Bagherzadeh Alireza Ghasempour Omid Pourdakan Reza Adl Seyed Jalal Kiani Mehdi Mirzaei Bita Mehravi
author_facet	Angila Ataei-Pirkooh Ali Alavi Mehran Kianirad Kowsar Bagherzadeh Alireza Ghasempour Omid Pourdakan Reza Adl Seyed Jalal Kiani Mehdi Mirzaei Bita Mehravi
author_sort	Angila Ataei-Pirkooh
title	Destruction mechanisms of ozone over SARS-CoV-2
title_short	Destruction mechanisms of ozone over SARS-CoV-2
title_full	Destruction mechanisms of ozone over SARS-CoV-2
title_fullStr	Destruction mechanisms of ozone over SARS-CoV-2
title_full_unstemmed	Destruction mechanisms of ozone over SARS-CoV-2
title_sort	destruction mechanisms of ozone over sars-cov-2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d2c84c5066bd414a9f61eba2628dcfdd
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Destruction mechanisms of ozone over SARS-CoV-2

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