Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Govindi J. Samaranayake, Clara I. Troccoli, Mai Huynh, Rolando D. Z. Lyles, Karen Kage, Andrew Win, Vishalakshi Lakshmanan, Deukwoo Kwon, Yuguang Ban, Steven Xi Chen, Enrique Rodriguez Zarco, Merce Jorda, Kerry L. Burnstein, Priyamvada Rai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2ca0dbfe1e54bac82aeb4b72d117967
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2ca0dbfe1e54bac82aeb4b72d117967
record_format	dspace
spelling	oai:doaj.org-article:d2ca0dbfe1e54bac82aeb4b72d1179672021-12-02T15:37:00ZThioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer10.1038/s41467-017-01269-x2041-1723https://doaj.org/article/d2ca0dbfe1e54bac82aeb4b72d1179672017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01269-xhttps://doaj.org/toc/2041-1723Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and androgen receptor expression.Govindi J. SamaranayakeClara I. TroccoliMai HuynhRolando D. Z. LylesKaren KageAndrew WinVishalakshi LakshmananDeukwoo KwonYuguang BanSteven Xi ChenEnrique Rodriguez ZarcoMerce JordaKerry L. BurnsteinPriyamvada RaiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Govindi J. Samaranayake Clara I. Troccoli Mai Huynh Rolando D. Z. Lyles Karen Kage Andrew Win Vishalakshi Lakshmanan Deukwoo Kwon Yuguang Ban Steven Xi Chen Enrique Rodriguez Zarco Merce Jorda Kerry L. Burnstein Priyamvada Rai Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
description	Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and androgen receptor expression.
format	article
author	Govindi J. Samaranayake Clara I. Troccoli Mai Huynh Rolando D. Z. Lyles Karen Kage Andrew Win Vishalakshi Lakshmanan Deukwoo Kwon Yuguang Ban Steven Xi Chen Enrique Rodriguez Zarco Merce Jorda Kerry L. Burnstein Priyamvada Rai
author_facet	Govindi J. Samaranayake Clara I. Troccoli Mai Huynh Rolando D. Z. Lyles Karen Kage Andrew Win Vishalakshi Lakshmanan Deukwoo Kwon Yuguang Ban Steven Xi Chen Enrique Rodriguez Zarco Merce Jorda Kerry L. Burnstein Priyamvada Rai
author_sort	Govindi J. Samaranayake
title	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
title_short	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
title_full	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
title_fullStr	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
title_full_unstemmed	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
title_sort	thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2ca0dbfe1e54bac82aeb4b72d117967
work_keys_str_mv	AT govindijsamaranayake thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT claraitroccoli thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT maihuynh thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT rolandodzlyles thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT karenkage thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT andrewwin thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT vishalakshilakshmanan thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT deukwookwon thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT yuguangban thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT stevenxichen thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT enriquerodriguezzarco thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT mercejorda thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT kerrylburnstein thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer AT priyamvadarai thioredoxin1protectsagainstandrogenreceptorinducedredoxvulnerabilityincastrationresistantprostatecancer
_version_	1718386318603452416

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

Ejemplares similares