Food intake precipitates seizures in temporal lobe epilepsy

Abstract Various factors have been considered as potential seizure precipitants. We here assessed the temporal association of food intake and seizure occurrence, and characteristics of seizures and epilepsy syndromes involved. 596 seizures from 100 consecutive patients undergoing long-term video-EEG...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dalma Tényi, József Janszky, Sára Jeges, Andreas Schulze-Bonhage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2d5f423ce3b4f738a84af3c797c8d43
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d2d5f423ce3b4f738a84af3c797c8d43
record_format	dspace
spelling	oai:doaj.org-article:d2d5f423ce3b4f738a84af3c797c8d432021-12-02T18:50:59ZFood intake precipitates seizures in temporal lobe epilepsy10.1038/s41598-021-96106-z2045-2322https://doaj.org/article/d2d5f423ce3b4f738a84af3c797c8d432021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96106-zhttps://doaj.org/toc/2045-2322Abstract Various factors have been considered as potential seizure precipitants. We here assessed the temporal association of food intake and seizure occurrence, and characteristics of seizures and epilepsy syndromes involved. 596 seizures from 100 consecutive patients undergoing long-term video-EEG monitoring were analyzed. Preictal periods of 60 min were assessed as to the occurrence of food intake, and latencies between food intake and seizure onset were analyzed. Seizures of temporal origin were highly significantly more frequently preceded by food intake compared to those of extratemporal origin; and were associated with shorter food intake-seizure latency. Seizure precipitation by food intake showed male predominance. Shorter food intake-seizure latency was associated with less severe seizures and less frequent contralateral spread of epileptic discharges. We here show for the first time that not only in specific rare reflex epilepsies but in the most frequent form of focal epilepsy, temporal lobe epilepsy, seizures are significantly precipitated by food intake. Seizure occurrence was increased over a period of up to one hour following food intake, and remained more localized in terms of both ictal EEG spread and as reflected by seizure severity. This finding supports the emerging concepts of ictogenesis, implying a continuum between reflex and spontaneous seizures—instead a dichotomy between them.Dalma TényiJózsef JanszkySára JegesAndreas Schulze-BonhageNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dalma Tényi József Janszky Sára Jeges Andreas Schulze-Bonhage Food intake precipitates seizures in temporal lobe epilepsy
description	Abstract Various factors have been considered as potential seizure precipitants. We here assessed the temporal association of food intake and seizure occurrence, and characteristics of seizures and epilepsy syndromes involved. 596 seizures from 100 consecutive patients undergoing long-term video-EEG monitoring were analyzed. Preictal periods of 60 min were assessed as to the occurrence of food intake, and latencies between food intake and seizure onset were analyzed. Seizures of temporal origin were highly significantly more frequently preceded by food intake compared to those of extratemporal origin; and were associated with shorter food intake-seizure latency. Seizure precipitation by food intake showed male predominance. Shorter food intake-seizure latency was associated with less severe seizures and less frequent contralateral spread of epileptic discharges. We here show for the first time that not only in specific rare reflex epilepsies but in the most frequent form of focal epilepsy, temporal lobe epilepsy, seizures are significantly precipitated by food intake. Seizure occurrence was increased over a period of up to one hour following food intake, and remained more localized in terms of both ictal EEG spread and as reflected by seizure severity. This finding supports the emerging concepts of ictogenesis, implying a continuum between reflex and spontaneous seizures—instead a dichotomy between them.
format	article
author	Dalma Tényi József Janszky Sára Jeges Andreas Schulze-Bonhage
author_facet	Dalma Tényi József Janszky Sára Jeges Andreas Schulze-Bonhage
author_sort	Dalma Tényi
title	Food intake precipitates seizures in temporal lobe epilepsy
title_short	Food intake precipitates seizures in temporal lobe epilepsy
title_full	Food intake precipitates seizures in temporal lobe epilepsy
title_fullStr	Food intake precipitates seizures in temporal lobe epilepsy
title_full_unstemmed	Food intake precipitates seizures in temporal lobe epilepsy
title_sort	food intake precipitates seizures in temporal lobe epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d2d5f423ce3b4f738a84af3c797c8d43
work_keys_str_mv	AT dalmatenyi foodintakeprecipitatesseizuresintemporallobeepilepsy AT jozsefjanszky foodintakeprecipitatesseizuresintemporallobeepilepsy AT sarajeges foodintakeprecipitatesseizuresintemporallobeepilepsy AT andreasschulzebonhage foodintakeprecipitatesseizuresintemporallobeepilepsy
_version_	1718377472797442048

Food intake precipitates seizures in temporal lobe epilepsy

Ejemplares similares