Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.

Slow conduction areas and conduction block in the atria are considered pro-arrhythmic conditions. Studies examining the size and distribution of slow conduction regions in the context of persistent atrial fibrillation (AF) may help to develop improved therapeutic strategies for patients with AF. In...

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Autores principales:	Matthias Lange, Annie M Hirahara, Ravi Ranjan, Gregory J Stoddard, Derek J Dosdall
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2d635393d3348fe81eb89c7bb50ae57
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spelling	oai:doaj.org-article:d2d635393d3348fe81eb89c7bb50ae572021-12-02T20:13:46ZAtrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.1932-620310.1371/journal.pone.0258285https://doaj.org/article/d2d635393d3348fe81eb89c7bb50ae572021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258285https://doaj.org/toc/1932-6203Slow conduction areas and conduction block in the atria are considered pro-arrhythmic conditions. Studies examining the size and distribution of slow conduction regions in the context of persistent atrial fibrillation (AF) may help to develop improved therapeutic strategies for patients with AF. In this work, we studied the differences of size and number in slow conduction areas between control and persistent AF goats and the influence of propagation direction on the development of these pathological conduction areas. Epicardial atrial electrical activations from the left atrial roof were optically mapped with physiological pacing cycle lengths and for the shortest captured cycle lengths. The recordings were converted to local activation times and conduction velocity measures. Regions with slow conduction velocity (less than [Formula: see text]) were identified. The size of the connected regions and the number of non-connected regions were counted for propagation from different orthogonal directions. We found that regions of slow conduction significantly increases in our 15 persistent AF goat recordings in response to premature stimulation (24.4±4.3% increase to 36.6±4.4%, p < 0.001). This increase is driven by an increase of size from (3.70±0.89[mm2] to 6.36±0.91[mm2], p = 0.014) for already existing regions and not by generation of new slow conduction regions (11.6±1.8 vs. 13±1.9, p = 0.242). In 12 control goat recordings, no increase from baseline pacing to premature pacing was found. Similarly, size of the slow conduction areas and the count did not change significantly in control animals.Matthias LangeAnnie M HiraharaRavi RanjanGregory J StoddardDerek J DosdallPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthias Lange Annie M Hirahara Ravi Ranjan Gregory J Stoddard Derek J Dosdall Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
description	Slow conduction areas and conduction block in the atria are considered pro-arrhythmic conditions. Studies examining the size and distribution of slow conduction regions in the context of persistent atrial fibrillation (AF) may help to develop improved therapeutic strategies for patients with AF. In this work, we studied the differences of size and number in slow conduction areas between control and persistent AF goats and the influence of propagation direction on the development of these pathological conduction areas. Epicardial atrial electrical activations from the left atrial roof were optically mapped with physiological pacing cycle lengths and for the shortest captured cycle lengths. The recordings were converted to local activation times and conduction velocity measures. Regions with slow conduction velocity (less than [Formula: see text]) were identified. The size of the connected regions and the number of non-connected regions were counted for propagation from different orthogonal directions. We found that regions of slow conduction significantly increases in our 15 persistent AF goat recordings in response to premature stimulation (24.4±4.3% increase to 36.6±4.4%, p < 0.001). This increase is driven by an increase of size from (3.70±0.89[mm2] to 6.36±0.91[mm2], p = 0.014) for already existing regions and not by generation of new slow conduction regions (11.6±1.8 vs. 13±1.9, p = 0.242). In 12 control goat recordings, no increase from baseline pacing to premature pacing was found. Similarly, size of the slow conduction areas and the count did not change significantly in control animals.
format	article
author	Matthias Lange Annie M Hirahara Ravi Ranjan Gregory J Stoddard Derek J Dosdall
author_facet	Matthias Lange Annie M Hirahara Ravi Ranjan Gregory J Stoddard Derek J Dosdall
author_sort	Matthias Lange
title	Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
title_short	Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
title_full	Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
title_fullStr	Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
title_full_unstemmed	Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
title_sort	atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d2d635393d3348fe81eb89c7bb50ae57
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Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.

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