The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases
Background. The imbalance of innate defense early mechanisms in children from pathogens — peroxidation and antioxidant system, can lead to a decrease in the efficiency of the entire immune system. The study of the lipid peroxidation (LPO) and antioxidant protection (AOP) status in children with recu...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN RU UK |
| Publicado: |
Publishing House Zaslavsky
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d2dbe10178594d9a9807ad94331d8868 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d2dbe10178594d9a9807ad94331d8868 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d2dbe10178594d9a9807ad94331d88682021-11-24T09:59:26ZThe systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases2224-05512307-116810.22141/2224-0551.16.7.2021.244575https://doaj.org/article/d2dbe10178594d9a9807ad94331d88682021-11-01T00:00:00Zhttp://childshealth.zaslavsky.com.ua/article/view/244575https://doaj.org/toc/2224-0551https://doaj.org/toc/2307-1168Background. The imbalance of innate defense early mechanisms in children from pathogens — peroxidation and antioxidant system, can lead to a decrease in the efficiency of the entire immune system. The study of the lipid peroxidation (LPO) and antioxidant protection (AOP) status in children with recurrent acute respiratory diseases will complement the scientific data on the antimicrobial immunity formation processes. The study was aimed to increase the information value of timely detected pro- and antioxidant processes disorders in children with recurrent acute respiratory diseases by studying the primary, secondary, tertiary, and quaternary compounds of LPO and AOP in the serum. Materials and methods. Sixty children aged from 2 to 5 years were examined. Two groups were formed: group 1 — children with respiratory acute infectious more than six times per year (n = 30); group 2 — children with respiratory acute infectious six or fewer times per year (n = 30). Results. The children in group 1 more often presented with high serum levels of lipid hydroperoxides (by 80.0 %; p < 0.05), diene conjugates (by 80.0 %; p < 0.05), malonic dialdehyde (76.7 %; p < 0.05), diene ketones (76.7 %; p < 0.05), Schiff bases (76.7 %; p < 0.05). ceruloplasmin (80.0 %; p < 0.05), superoxide dismutase (80.0 %; p < 0.05), glutathione peroxidase (86.7 %; p < 0.05), catalase activity (86.7 %; p < 0.05). The values of retinol, tocopherol, ascorbic acid in children in the observation groups did not differ statistically significantly. Conclusions. The children aged from 2 to 5 years old with recurrent acute respiratory diseases have an imbalance of the LPO and AOP systems. It was characterized by a simultaneous increase in the serum content of the primary, secondary, and end-products of LPO, enzymes of anti-peroxide and anti-oxygen protection against the background of the lack of adaptive increase in the content of anti-radical compounds.L.S. OvcharenkoO.V. TymoshynaA.O. VertehelT.G. AndrienkoI.V. SamokhinO.V. KryazhevO.M. ChakmazovaPublishing House Zaslavskyarticlechildren, peroxidation, anti-oxidant protection, infectionPediatricsRJ1-570ENRUUKZdorovʹe Rebenka, Vol 16, Iss 7, Pp 461-466 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN RU UK |
| topic |
children, peroxidation, anti-oxidant protection, infection Pediatrics RJ1-570 |
| spellingShingle |
children, peroxidation, anti-oxidant protection, infection Pediatrics RJ1-570 L.S. Ovcharenko O.V. Tymoshyna A.O. Vertehel T.G. Andrienko I.V. Samokhin O.V. Kryazhev O.M. Chakmazova The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| description |
Background. The imbalance of innate defense early mechanisms in children from pathogens — peroxidation and antioxidant system, can lead to a decrease in the efficiency of the entire immune system. The study of the lipid peroxidation (LPO) and antioxidant protection (AOP) status in children with recurrent acute respiratory diseases will complement the scientific data on the antimicrobial immunity formation processes. The study was aimed to increase the information value of timely detected pro- and antioxidant processes disorders in children with recurrent acute respiratory diseases by studying the primary, secondary, tertiary, and quaternary compounds of LPO and AOP in the serum. Materials and methods. Sixty children aged from 2 to 5 years were examined. Two groups were formed: group 1 — children with respiratory acute infectious more than six times per year (n = 30); group 2 — children with respiratory acute infectious six or fewer times per year (n = 30). Results. The children in group 1 more often presented with high serum levels of lipid hydroperoxides (by 80.0 %; p < 0.05), diene conjugates (by 80.0 %; p < 0.05), malonic dialdehyde (76.7 %; p < 0.05), diene ketones (76.7 %; p < 0.05), Schiff bases (76.7 %; p < 0.05). ceruloplasmin (80.0 %; p < 0.05), superoxide dismutase (80.0 %; p < 0.05), glutathione peroxidase (86.7 %; p < 0.05), catalase activity (86.7 %; p < 0.05). The values of retinol, tocopherol, ascorbic acid in children in the observation groups did not differ statistically significantly. Conclusions. The children aged from 2 to 5 years old with recurrent acute respiratory diseases have an imbalance of the LPO and AOP systems. It was characterized by a simultaneous increase in the serum content of the primary, secondary, and end-products of LPO, enzymes of anti-peroxide and anti-oxygen protection against the background of the lack of adaptive increase in the content of anti-radical compounds. |
| format |
article |
| author |
L.S. Ovcharenko O.V. Tymoshyna A.O. Vertehel T.G. Andrienko I.V. Samokhin O.V. Kryazhev O.M. Chakmazova |
| author_facet |
L.S. Ovcharenko O.V. Tymoshyna A.O. Vertehel T.G. Andrienko I.V. Samokhin O.V. Kryazhev O.M. Chakmazova |
| author_sort |
L.S. Ovcharenko |
| title |
The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| title_short |
The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| title_full |
The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| title_fullStr |
The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| title_full_unstemmed |
The systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| title_sort |
systemic pro- and antioxidant processes in preschool children with recurrent acute respiratory diseases |
| publisher |
Publishing House Zaslavsky |
| publishDate |
2021 |
| url |
https://doaj.org/article/d2dbe10178594d9a9807ad94331d8868 |
| work_keys_str_mv |
AT lsovcharenko thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ovtymoshyna thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT aovertehel thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT tgandrienko thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ivsamokhin thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ovkryazhev thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT omchakmazova thesystemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT lsovcharenko systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ovtymoshyna systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT aovertehel systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT tgandrienko systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ivsamokhin systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT ovkryazhev systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases AT omchakmazova systemicproandantioxidantprocessesinpreschoolchildrenwithrecurrentacuterespiratorydiseases |
| _version_ |
1718415133245440000 |