Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the immunoproteasome (IP). The in vivo function of IPs in...

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Bibliographic Details
Main Authors: Elisa Opitz, Annett Koch, Karin Klingel, Frank Schmidt, Stefan Prokop, Anna Rahnefeld, Martina Sauter, Frank L Heppner, Uwe Völker, Reinhard Kandolf, Ulrike Kuckelkorn, Karl Stangl, Elke Krüger, Peter M Kloetzel, Antje Voigt
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/d2dbeb93a01945528f41de1fbc1d9375
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https://doaj.org/article/d2dbeb93a01945528f41de1fbc1d9375

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