Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.
Proteasomes recognize and degrade poly-ubiquitinylated proteins. In infectious disease, cells activated by interferons (IFNs) express three unique catalytic subunits β1i/LMP2, β2i/MECL-1 and β5i/LMP7 forming an alternative proteasome isoform, the immunoproteasome (IP). The in vivo function of IPs in...
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Autores principales: | Elisa Opitz, Annett Koch, Karin Klingel, Frank Schmidt, Stefan Prokop, Anna Rahnefeld, Martina Sauter, Frank L Heppner, Uwe Völker, Reinhard Kandolf, Ulrike Kuckelkorn, Karl Stangl, Elke Krüger, Peter M Kloetzel, Antje Voigt |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
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Materias: | |
Acceso en línea: | https://doaj.org/article/d2dbeb93a01945528f41de1fbc1d9375 |
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