The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer
ObjectiveThe present study aimed to evaluate the role of integrating the pretreatment neutrophil-to-lymphocyte ratio (NLR) into the eighth edition of the AJCC staging system for nasopharynx cancer in an endemic region.MethodsBetween May 2007 and December 2012, a total of 713 cases with NPC were retr...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d2df60f517454c6a84996da5085529012021-11-11T08:14:23ZThe Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer2234-943X10.3389/fonc.2021.724467https://doaj.org/article/d2df60f517454c6a84996da5085529012021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.724467/fullhttps://doaj.org/toc/2234-943XObjectiveThe present study aimed to evaluate the role of integrating the pretreatment neutrophil-to-lymphocyte ratio (NLR) into the eighth edition of the AJCC staging system for nasopharynx cancer in an endemic region.MethodsBetween May 2007 and December 2012, a total of 713 cases with NPC were retrospectively analyzed. The separation ability in terms of overall survival (OS), local failure-free survival (LFFS), distant metastasis-free survival (DMFS), and failure-free survival (FFS) was evaluated. The discriminatory ability was assessed using Harrell’s concordance index (c-index). Recursive partitioning analysis (RPA) was conducted and incorporated with pretreatment NLR.ResultsWhen integrated with NLR, the separate and discriminatory abilities for N classifications were improved in terms of OS and DMFS, but not for T categories. By using Recursive partitioning analysis, five subgroups were generated. Compared with the overall stage, the integration of NLR could not enhance the separate and discriminatory abilities. However, patients in the RPA 4 group gained significant benefits in terms of OS (HR 0.390 (95%CI 0.212-0.716), P = 0.002) and FFS (HR 0.548 (95%CI 0.314-0.958), P = 0.032) from the additional adjuvant chemotherapy after concurrent chemoradiotherapy.ConclusionThe integration of NLR into the 8th edition of the AJCC staging system could enhance the separation and discriminatory abilities for N classifications, but not for T categories. In addition, patients in the RPA 4 group could benefit from the addition of adjuvant chemotherapy to concurrent chemoradiotherapy.Zhong-Guo LiangFan ZhangYe LiLing LiSong QuFang SuBin-Bin YuYing GuanLu HanKai-Guo LiXiao-Dong ZhuFrontiers Media S.A.articlenasopharynx cancer (NPC)neutrophil-to-lymphocyte ratio (NLR)neoplasm stagingconcurrent chemoradiotherapy (CCRT)adjuvant chemotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
nasopharynx cancer (NPC) neutrophil-to-lymphocyte ratio (NLR) neoplasm staging concurrent chemoradiotherapy (CCRT) adjuvant chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
nasopharynx cancer (NPC) neutrophil-to-lymphocyte ratio (NLR) neoplasm staging concurrent chemoradiotherapy (CCRT) adjuvant chemotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhong-Guo Liang Fan Zhang Ye Li Ling Li Song Qu Fang Su Bin-Bin Yu Ying Guan Lu Han Kai-Guo Li Xiao-Dong Zhu The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| description |
ObjectiveThe present study aimed to evaluate the role of integrating the pretreatment neutrophil-to-lymphocyte ratio (NLR) into the eighth edition of the AJCC staging system for nasopharynx cancer in an endemic region.MethodsBetween May 2007 and December 2012, a total of 713 cases with NPC were retrospectively analyzed. The separation ability in terms of overall survival (OS), local failure-free survival (LFFS), distant metastasis-free survival (DMFS), and failure-free survival (FFS) was evaluated. The discriminatory ability was assessed using Harrell’s concordance index (c-index). Recursive partitioning analysis (RPA) was conducted and incorporated with pretreatment NLR.ResultsWhen integrated with NLR, the separate and discriminatory abilities for N classifications were improved in terms of OS and DMFS, but not for T categories. By using Recursive partitioning analysis, five subgroups were generated. Compared with the overall stage, the integration of NLR could not enhance the separate and discriminatory abilities. However, patients in the RPA 4 group gained significant benefits in terms of OS (HR 0.390 (95%CI 0.212-0.716), P = 0.002) and FFS (HR 0.548 (95%CI 0.314-0.958), P = 0.032) from the additional adjuvant chemotherapy after concurrent chemoradiotherapy.ConclusionThe integration of NLR into the 8th edition of the AJCC staging system could enhance the separation and discriminatory abilities for N classifications, but not for T categories. In addition, patients in the RPA 4 group could benefit from the addition of adjuvant chemotherapy to concurrent chemoradiotherapy. |
| format |
article |
| author |
Zhong-Guo Liang Fan Zhang Ye Li Ling Li Song Qu Fang Su Bin-Bin Yu Ying Guan Lu Han Kai-Guo Li Xiao-Dong Zhu |
| author_facet |
Zhong-Guo Liang Fan Zhang Ye Li Ling Li Song Qu Fang Su Bin-Bin Yu Ying Guan Lu Han Kai-Guo Li Xiao-Dong Zhu |
| author_sort |
Zhong-Guo Liang |
| title |
The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| title_short |
The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| title_full |
The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| title_fullStr |
The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| title_full_unstemmed |
The Integration of the Pre-Treatment Neutrophil-to-Lymphocyte Ratio in the Eighth Edition of the AJCC Staging System for Nasopharynx Cancer |
| title_sort |
integration of the pre-treatment neutrophil-to-lymphocyte ratio in the eighth edition of the ajcc staging system for nasopharynx cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d2df60f517454c6a84996da508552901 |
| work_keys_str_mv |
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