Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.

<h4>Background</h4>To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.<h4>Methods</h4>We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was...

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Autores principales:	Peng Wang, Xing Wang, Haidong Deng, Linjie Li, Weelic Chong, Yang Hai, Yu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2e2cd014a864bb68185837f7a38d352
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spelling	oai:doaj.org-article:d2e2cd014a864bb68185837f7a38d3522021-12-02T20:19:21ZRestrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.1932-620310.1371/journal.pone.0256810https://doaj.org/article/d2e2cd014a864bb68185837f7a38d3522021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256810https://doaj.org/toc/1932-6203<h4>Background</h4>To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.<h4>Methods</h4>We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was conducted in August 15, 2020. All randomized controlled trials comparing the use of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight (VLBW) infants were selected. Pooled risk ratio (RR) for dichotomous variable with 95% confidence intervals were assessed by a random-effects model. The primary outcome was all-cause mortality.<h4>Results</h4>Overall, this meta-analysis included 6 randomized controlled trials comprising 3,483 participants. Restrictive transfusion does not increase the risk of all-cause mortality (RR, 0.99; 95% CI, 0.84 to 1.17; I2 = 0%; high-quality evidence), and does not increase the composite outcome of death or neurodevelopmental impairment (RR, 1.01, 95% CI, 0.93-1.09; I2 = 7%; high-quality evidence) or other serious adverse events. Results were similar in subgroup analyses of all-cause mortality by weight of infants, gestational age, male infants, and transfusion volume.<h4>Conclusions</h4>In very low birth weight infants, a restrictive threshold for red blood cell transfusion was not associated with increased risk of all-cause mortality, in either short term or long term.Peng WangXing WangHaidong DengLinjie LiWeelic ChongYang HaiYu ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256810 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peng Wang Xing Wang Haidong Deng Linjie Li Weelic Chong Yang Hai Yu Zhang Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
description	<h4>Background</h4>To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.<h4>Methods</h4>We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was conducted in August 15, 2020. All randomized controlled trials comparing the use of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight (VLBW) infants were selected. Pooled risk ratio (RR) for dichotomous variable with 95% confidence intervals were assessed by a random-effects model. The primary outcome was all-cause mortality.<h4>Results</h4>Overall, this meta-analysis included 6 randomized controlled trials comprising 3,483 participants. Restrictive transfusion does not increase the risk of all-cause mortality (RR, 0.99; 95% CI, 0.84 to 1.17; I2 = 0%; high-quality evidence), and does not increase the composite outcome of death or neurodevelopmental impairment (RR, 1.01, 95% CI, 0.93-1.09; I2 = 7%; high-quality evidence) or other serious adverse events. Results were similar in subgroup analyses of all-cause mortality by weight of infants, gestational age, male infants, and transfusion volume.<h4>Conclusions</h4>In very low birth weight infants, a restrictive threshold for red blood cell transfusion was not associated with increased risk of all-cause mortality, in either short term or long term.
format	article
author	Peng Wang Xing Wang Haidong Deng Linjie Li Weelic Chong Yang Hai Yu Zhang
author_facet	Peng Wang Xing Wang Haidong Deng Linjie Li Weelic Chong Yang Hai Yu Zhang
author_sort	Peng Wang
title	Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
title_short	Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
title_full	Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
title_fullStr	Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
title_full_unstemmed	Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.
title_sort	restrictive versus liberal transfusion thresholds in very low birth weight infants: a systematic review with meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d2e2cd014a864bb68185837f7a38d352
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Restrictive versus liberal transfusion thresholds in very low birth weight infants: A systematic review with meta-analysis.

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