Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China

Abstract Background Xinjiang is one of the regions with a high incidence of cervical cancer, and the genetic variation of human papillomavirus may increase its ability to infect the human body and enhance virus-mediated immune escape ability. Methods Sanger sequencing of the HPV16 genome from 165 sa...

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Autores principales:	Luyue Wang, Fang Wang, Shaowei Fu, Chunhe Zhang, Xiangyi Zhe, Hongtao Li, Dongmei Li, Renfu Shao, Zemin Pan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cervical exfoliated cells Human papillomavirus E1 and E2 genes Genetic polymorphism Sanger sequencing Internal medicine RC31-1245 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/d2e422dbd3fd498aba78850fb3622dea
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spelling	oai:doaj.org-article:d2e422dbd3fd498aba78850fb3622dea2021-11-14T12:07:40ZAnalysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China10.1186/s12920-021-01120-91755-8794https://doaj.org/article/d2e422dbd3fd498aba78850fb3622dea2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12920-021-01120-9https://doaj.org/toc/1755-8794Abstract Background Xinjiang is one of the regions with a high incidence of cervical cancer, and the genetic variation of human papillomavirus may increase its ability to infect the human body and enhance virus-mediated immune escape ability. Methods Sanger sequencing of the HPV16 genome from 165 samples positive for HPV16 infection and phylogenetic analysis of the E1 and E2 genes revealed the gene polymorphism of HPV16 in Xinjiang. Results The results showed that there were 109 samples with variations in HPV16 E1, 48 sites with nucleotide variations (19 missense variations and 29 synonymous variations), and 91 samples with variations in HPV16 E2, 25 sites with nucleotide variations (20 missense variations and five synonymous variations). Conclusions From the phylogenetic tree results, 149 samples were of the European variant and 16 samples were of the Asian variant. No African or North American/Asian variant types were found.Luyue WangFang WangShaowei FuChunhe ZhangXiangyi ZheHongtao LiDongmei LiRenfu ShaoZemin PanBMCarticleCervical exfoliated cellsHuman papillomavirusE1 and E2 genesGenetic polymorphismSanger sequencingInternal medicineRC31-1245GeneticsQH426-470ENBMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical exfoliated cells Human papillomavirus E1 and E2 genes Genetic polymorphism Sanger sequencing Internal medicine RC31-1245 Genetics QH426-470
spellingShingle	Cervical exfoliated cells Human papillomavirus E1 and E2 genes Genetic polymorphism Sanger sequencing Internal medicine RC31-1245 Genetics QH426-470 Luyue Wang Fang Wang Shaowei Fu Chunhe Zhang Xiangyi Zhe Hongtao Li Dongmei Li Renfu Shao Zemin Pan Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
description	Abstract Background Xinjiang is one of the regions with a high incidence of cervical cancer, and the genetic variation of human papillomavirus may increase its ability to infect the human body and enhance virus-mediated immune escape ability. Methods Sanger sequencing of the HPV16 genome from 165 samples positive for HPV16 infection and phylogenetic analysis of the E1 and E2 genes revealed the gene polymorphism of HPV16 in Xinjiang. Results The results showed that there were 109 samples with variations in HPV16 E1, 48 sites with nucleotide variations (19 missense variations and 29 synonymous variations), and 91 samples with variations in HPV16 E2, 25 sites with nucleotide variations (20 missense variations and five synonymous variations). Conclusions From the phylogenetic tree results, 149 samples were of the European variant and 16 samples were of the Asian variant. No African or North American/Asian variant types were found.
format	article
author	Luyue Wang Fang Wang Shaowei Fu Chunhe Zhang Xiangyi Zhe Hongtao Li Dongmei Li Renfu Shao Zemin Pan
author_facet	Luyue Wang Fang Wang Shaowei Fu Chunhe Zhang Xiangyi Zhe Hongtao Li Dongmei Li Renfu Shao Zemin Pan
author_sort	Luyue Wang
title	Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
title_short	Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
title_full	Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
title_fullStr	Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
title_full_unstemmed	Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China
title_sort	analysis of genetic variation in human papillomavirus type 16 e1 and e2 in women with cervical infection in xinjiang, china
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d2e422dbd3fd498aba78850fb3622dea
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Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China

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