Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.

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Autores principales:	Juliana M. Sá, Sarah R. Kaslow, Roberto R. Moraes Barros, Nicholas F. Brazeau, Christian M. Parobek, Dingyin Tao, Rebecca E. Salzman, Tyler J. Gibson, Soundarapandian Velmurugan, Michael A. Krause, Viviana Melendez-Muniz, Whitney A. Kite, Paul K. Han, Richard T. Eastman, Adam Kim, Evan G. Kessler, Yonas Abebe, Eric R. James, Sumana Chakravarty, Sachy Orr-Gonzalez, Lynn E. Lambert, Theresa Engels, Marvin L. Thomas, Pius S. Fasinu, David Serre, Robert W. Gwadz, Larry Walker, Derrick K. DeConti, Jianbing Mu, Jeffrey A. Bailey, B. Kim Lee Sim, Stephen L. Hoffman, Michael P. Fay, Rhoel R. Dinglasan, Jonathan J. Juliano, Thomas E. Wellems
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2e5b78b5b7d41ea85f525fdaf910313
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spelling	oai:doaj.org-article:d2e5b78b5b7d41ea85f525fdaf9103132021-12-02T14:38:59ZPlasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross10.1038/s41467-019-12256-92041-1723https://doaj.org/article/d2e5b78b5b7d41ea85f525fdaf9103132019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12256-9https://doaj.org/toc/2041-1723Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.Juliana M. SáSarah R. KaslowRoberto R. Moraes BarrosNicholas F. BrazeauChristian M. ParobekDingyin TaoRebecca E. SalzmanTyler J. GibsonSoundarapandian VelmuruganMichael A. KrauseViviana Melendez-MunizWhitney A. KitePaul K. HanRichard T. EastmanAdam KimEvan G. KesslerYonas AbebeEric R. JamesSumana ChakravartySachy Orr-GonzalezLynn E. LambertTheresa EngelsMarvin L. ThomasPius S. FasinuDavid SerreRobert W. GwadzLarry WalkerDerrick K. DeContiJianbing MuJeffrey A. BaileyB. Kim Lee SimStephen L. HoffmanMichael P. FayRhoel R. DinglasanJonathan J. JulianoThomas E. WellemsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
description	Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.
format	article
author	Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems
author_facet	Juliana M. Sá Sarah R. Kaslow Roberto R. Moraes Barros Nicholas F. Brazeau Christian M. Parobek Dingyin Tao Rebecca E. Salzman Tyler J. Gibson Soundarapandian Velmurugan Michael A. Krause Viviana Melendez-Muniz Whitney A. Kite Paul K. Han Richard T. Eastman Adam Kim Evan G. Kessler Yonas Abebe Eric R. James Sumana Chakravarty Sachy Orr-Gonzalez Lynn E. Lambert Theresa Engels Marvin L. Thomas Pius S. Fasinu David Serre Robert W. Gwadz Larry Walker Derrick K. DeConti Jianbing Mu Jeffrey A. Bailey B. Kim Lee Sim Stephen L. Hoffman Michael P. Fay Rhoel R. Dinglasan Jonathan J. Juliano Thomas E. Wellems
author_sort	Juliana M. Sá
title	Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
title_short	Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
title_full	Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
title_fullStr	Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
title_full_unstemmed	Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
title_sort	plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d2e5b78b5b7d41ea85f525fdaf910313
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Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross

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