Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension

Abstract Background Little attention has been paid to chest high resolution computed tomography (HRCT) findings in idiopathic pulmonary arterial hypertension (IPAH) patients so far, while a couple of small studies suggested that presence of centrilobular ground-glass opacifications (GGO) on lung sca...

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Autores principales:	Aneta Kacprzak, Barbara Burakowska, Marcin Kurzyna, Anna Fijałkowska, Michał Florczyk, Maria Wieteska-Miłek, Szymon Darocha, Adam Torbicki, Monika Szturmowicz
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Idiopathic pulmonary arterial hypertension High resolution computed tomography Ground-glass opacifications Survival Risk factors Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/d2e60fc4c9c640348a0d35b32cc583ad
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spelling	oai:doaj.org-article:d2e60fc4c9c640348a0d35b32cc583ad2021-11-21T12:32:02ZPredictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension10.1186/s12931-021-01893-81465-993Xhttps://doaj.org/article/d2e60fc4c9c640348a0d35b32cc583ad2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12931-021-01893-8https://doaj.org/toc/1465-993XAbstract Background Little attention has been paid to chest high resolution computed tomography (HRCT) findings in idiopathic pulmonary arterial hypertension (IPAH) patients so far, while a couple of small studies suggested that presence of centrilobular ground-glass opacifications (GGO) on lung scans could have a significant negative prognostic value. Therefore, the aims of the present study were: to assess frequency and clinical significance of GGO in IPAH, and to verify if it carries an add-on prognostic value in reference to multidimensional risk assessment tool recommended by the 2015 European pulmonary hypertension guidelines. Methods Chest HRCT scans of 110 IPAH patients were retrospectively analysed. Patients were divided into three groups: with panlobular (p)GGO, centrilobular (c)GGO, and normal lung pattern. Association of different GGO patterns with demographic, functional, haemodynamic, and biochemical parameters was tested. Survival analysis was also performed. Results GGO were found in 46% of the IPAH patients: pGGO in 24% and cGGO in 22%. Independent predictors of pGGO were: positive history of haemoptysis, higher number of low-risk factors, and lower cardiac output. Independent predictors of cGGO were: positive history of haemoptysis, younger age, higher right atrial pressure, and higher mixed venous blood oxygen saturation. CGGO had a negative prognostic value for outcome in a 2-year perspective. This effect was not seen in the longer term, probably due to short survival of cGGO patients. Conclusions Lung HRCT carries a significant independent prognostic information in IPAH, and in patients with cGGO present on the scans an early referral to lung transplantation centres should be considered.Aneta KacprzakBarbara BurakowskaMarcin KurzynaAnna FijałkowskaMichał FlorczykMaria Wieteska-MiłekSzymon DarochaAdam TorbickiMonika SzturmowiczBMCarticleIdiopathic pulmonary arterial hypertensionHigh resolution computed tomographyGround-glass opacificationsSurvivalRisk factorsDiseases of the respiratory systemRC705-779ENRespiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Idiopathic pulmonary arterial hypertension High resolution computed tomography Ground-glass opacifications Survival Risk factors Diseases of the respiratory system RC705-779
spellingShingle	Idiopathic pulmonary arterial hypertension High resolution computed tomography Ground-glass opacifications Survival Risk factors Diseases of the respiratory system RC705-779 Aneta Kacprzak Barbara Burakowska Marcin Kurzyna Anna Fijałkowska Michał Florczyk Maria Wieteska-Miłek Szymon Darocha Adam Torbicki Monika Szturmowicz Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
description	Abstract Background Little attention has been paid to chest high resolution computed tomography (HRCT) findings in idiopathic pulmonary arterial hypertension (IPAH) patients so far, while a couple of small studies suggested that presence of centrilobular ground-glass opacifications (GGO) on lung scans could have a significant negative prognostic value. Therefore, the aims of the present study were: to assess frequency and clinical significance of GGO in IPAH, and to verify if it carries an add-on prognostic value in reference to multidimensional risk assessment tool recommended by the 2015 European pulmonary hypertension guidelines. Methods Chest HRCT scans of 110 IPAH patients were retrospectively analysed. Patients were divided into three groups: with panlobular (p)GGO, centrilobular (c)GGO, and normal lung pattern. Association of different GGO patterns with demographic, functional, haemodynamic, and biochemical parameters was tested. Survival analysis was also performed. Results GGO were found in 46% of the IPAH patients: pGGO in 24% and cGGO in 22%. Independent predictors of pGGO were: positive history of haemoptysis, higher number of low-risk factors, and lower cardiac output. Independent predictors of cGGO were: positive history of haemoptysis, younger age, higher right atrial pressure, and higher mixed venous blood oxygen saturation. CGGO had a negative prognostic value for outcome in a 2-year perspective. This effect was not seen in the longer term, probably due to short survival of cGGO patients. Conclusions Lung HRCT carries a significant independent prognostic information in IPAH, and in patients with cGGO present on the scans an early referral to lung transplantation centres should be considered.
format	article
author	Aneta Kacprzak Barbara Burakowska Marcin Kurzyna Anna Fijałkowska Michał Florczyk Maria Wieteska-Miłek Szymon Darocha Adam Torbicki Monika Szturmowicz
author_facet	Aneta Kacprzak Barbara Burakowska Marcin Kurzyna Anna Fijałkowska Michał Florczyk Maria Wieteska-Miłek Szymon Darocha Adam Torbicki Monika Szturmowicz
author_sort	Aneta Kacprzak
title	Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
title_short	Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
title_full	Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
title_fullStr	Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
title_full_unstemmed	Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension
title_sort	predictive value of chest hrct for survival in idiopathic pulmonary arterial hypertension
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d2e60fc4c9c640348a0d35b32cc583ad
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Predictive value of chest HRCT for survival in idiopathic pulmonary arterial hypertension

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