Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.

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Autores principales:	Ellis Chika Onwordi, Els F. Halff, Thomas Whitehurst, Ayla Mansur, Marie-Caroline Cotel, Lisa Wells, Hannah Creeney, David Bonsall, Maria Rogdaki, Ekaterina Shatalina, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Sridhar Natesan, Anthony C. Vernon, Oliver D. Howes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2e6a5e593d0405db0ad2d55f3b35447
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spelling	oai:doaj.org-article:d2e6a5e593d0405db0ad2d55f3b354472021-12-02T14:42:47ZSynaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats10.1038/s41467-019-14122-02041-1723https://doaj.org/article/d2e6a5e593d0405db0ad2d55f3b354472020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14122-0https://doaj.org/toc/2041-1723Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.Ellis Chika OnwordiEls F. HalffThomas WhitehurstAyla MansurMarie-Caroline CotelLisa WellsHannah CreeneyDavid BonsallMaria RogdakiEkaterina ShatalinaTiago Reis MarquesEugenii A. RabinerRoger N. GunnSridhar NatesanAnthony C. VernonOliver D. HowesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ellis Chika Onwordi Els F. Halff Thomas Whitehurst Ayla Mansur Marie-Caroline Cotel Lisa Wells Hannah Creeney David Bonsall Maria Rogdaki Ekaterina Shatalina Tiago Reis Marques Eugenii A. Rabiner Roger N. Gunn Sridhar Natesan Anthony C. Vernon Oliver D. Howes Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
description	Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.
format	article
author	Ellis Chika Onwordi Els F. Halff Thomas Whitehurst Ayla Mansur Marie-Caroline Cotel Lisa Wells Hannah Creeney David Bonsall Maria Rogdaki Ekaterina Shatalina Tiago Reis Marques Eugenii A. Rabiner Roger N. Gunn Sridhar Natesan Anthony C. Vernon Oliver D. Howes
author_facet	Ellis Chika Onwordi Els F. Halff Thomas Whitehurst Ayla Mansur Marie-Caroline Cotel Lisa Wells Hannah Creeney David Bonsall Maria Rogdaki Ekaterina Shatalina Tiago Reis Marques Eugenii A. Rabiner Roger N. Gunn Sridhar Natesan Anthony C. Vernon Oliver D. Howes
author_sort	Ellis Chika Onwordi
title	Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
title_short	Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
title_full	Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
title_fullStr	Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
title_full_unstemmed	Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
title_sort	synaptic density marker sv2a is reduced in schizophrenia patients and unaffected by antipsychotics in rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d2e6a5e593d0405db0ad2d55f3b35447
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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

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