Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients

Abstract Standard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2, who underwent PCR testing in one of fi...

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Autores principales:	Rainer Thell, Jascha Zimmermann, Marton Szell, Sabine Tomez, Philip Eisenburger, Moritz Haugk, Anna Kreil, Alexander Spiel, Amelie Blaschke, Anna Klicpera, Oskar Janata, Walter Krugluger, Christian Sebesta, Harald Herkner, Brenda Laky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2e9eb30632f4a459f75805b6caa1bb8
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spelling	oai:doaj.org-article:d2e9eb30632f4a459f75805b6caa1bb82021-12-02T17:15:16ZStandard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients10.1038/s41598-021-88844-x2045-2322https://doaj.org/article/d2e9eb30632f4a459f75805b6caa1bb82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88844-xhttps://doaj.org/toc/2045-2322Abstract Standard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2, who underwent PCR testing in one of five hospitals in Vienna, Austria. We compared laboratory parameters, clinical characteristics, and outcomes between positive and negative PCR-tested patients and evaluated the ability of those parameters to distinguish between groups. Of the 590 patients (20–100 years, 276 females and 314 males), 208 were PCR-positive. Positive compared to negative PCR-tested patients had significantly lower levels of leukocytes, neutrophils, basophils, eosinophils, lymphocytes, neutrophil-to-lymphocyte ratio, monocytes, and thrombocytes; while significantly higher levels were detected with erythrocytes, hemoglobin, hematocrit, C-reactive-protein, ferritin, activated-partial-thromboplastin-time, alanine-aminotransferase, aspartate-aminotransferase, lipase, creatine-kinase, and lactate-dehydrogenase. From all blood parameters, eosinophils, ferritin, leukocytes, and erythrocytes showed the highest ability to distinguish between COVID-19 positive and negative patients (area-under-curve, AUC: 72.3–79.4%). The AUC of our model was 0.915 (95% confidence intervals, 0.876–0.955). Leukopenia, eosinopenia, elevated erythrocytes, and hemoglobin were among the strongest markers regarding accuracy, sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio, and post-test probabilities. Our findings suggest that especially leukopenia, eosinopenia, and elevated hemoglobin are helpful to distinguish between COVID-19 positive and negative tested patients.Rainer ThellJascha ZimmermannMarton SzellSabine TomezPhilip EisenburgerMoritz HaugkAnna KreilAlexander SpielAmelie BlaschkeAnna KlicperaOskar JanataWalter KruglugerChristian SebestaHarald HerknerBrenda LakyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rainer Thell Jascha Zimmermann Marton Szell Sabine Tomez Philip Eisenburger Moritz Haugk Anna Kreil Alexander Spiel Amelie Blaschke Anna Klicpera Oskar Janata Walter Krugluger Christian Sebesta Harald Herkner Brenda Laky Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
description	Abstract Standard blood laboratory parameters may have diagnostic potential, if polymerase-chain-reaction (PCR) tests are not available on time. We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2, who underwent PCR testing in one of five hospitals in Vienna, Austria. We compared laboratory parameters, clinical characteristics, and outcomes between positive and negative PCR-tested patients and evaluated the ability of those parameters to distinguish between groups. Of the 590 patients (20–100 years, 276 females and 314 males), 208 were PCR-positive. Positive compared to negative PCR-tested patients had significantly lower levels of leukocytes, neutrophils, basophils, eosinophils, lymphocytes, neutrophil-to-lymphocyte ratio, monocytes, and thrombocytes; while significantly higher levels were detected with erythrocytes, hemoglobin, hematocrit, C-reactive-protein, ferritin, activated-partial-thromboplastin-time, alanine-aminotransferase, aspartate-aminotransferase, lipase, creatine-kinase, and lactate-dehydrogenase. From all blood parameters, eosinophils, ferritin, leukocytes, and erythrocytes showed the highest ability to distinguish between COVID-19 positive and negative patients (area-under-curve, AUC: 72.3–79.4%). The AUC of our model was 0.915 (95% confidence intervals, 0.876–0.955). Leukopenia, eosinopenia, elevated erythrocytes, and hemoglobin were among the strongest markers regarding accuracy, sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratio, and post-test probabilities. Our findings suggest that especially leukopenia, eosinopenia, and elevated hemoglobin are helpful to distinguish between COVID-19 positive and negative tested patients.
format	article
author	Rainer Thell Jascha Zimmermann Marton Szell Sabine Tomez Philip Eisenburger Moritz Haugk Anna Kreil Alexander Spiel Amelie Blaschke Anna Klicpera Oskar Janata Walter Krugluger Christian Sebesta Harald Herkner Brenda Laky
author_facet	Rainer Thell Jascha Zimmermann Marton Szell Sabine Tomez Philip Eisenburger Moritz Haugk Anna Kreil Alexander Spiel Amelie Blaschke Anna Klicpera Oskar Janata Walter Krugluger Christian Sebesta Harald Herkner Brenda Laky
author_sort	Rainer Thell
title	Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
title_short	Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
title_full	Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
title_fullStr	Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
title_full_unstemmed	Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients
title_sort	standard blood laboratory values as a clinical support tool to distinguish between sars-cov-2 positive and negative patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d2e9eb30632f4a459f75805b6caa1bb8
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Standard blood laboratory values as a clinical support tool to distinguish between SARS-CoV-2 positive and negative patients

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