Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

The molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT.

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Detalles Bibliográficos
Autores principales:	Athanasios Stergiopoulos, Panagiotis K. Politis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2ea2f8f4bcf413f89c3f2c566fc5f26
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spelling	oai:doaj.org-article:d2ea2f8f4bcf413f89c3f2c566fc5f262021-12-02T15:35:45ZNuclear receptor NR5A2 controls neural stem cell fate decisions during development10.1038/ncomms122302041-1723https://doaj.org/article/d2ea2f8f4bcf413f89c3f2c566fc5f262016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12230https://doaj.org/toc/2041-1723The molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT.Athanasios StergiopoulosPanagiotis K. PolitisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Athanasios Stergiopoulos Panagiotis K. Politis Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
description	The molecular signals regulating the decision of neural stem cells (NSC) to proliferate versus differentiate are unclear. Here, the authors identify the nuclear receptor NR5A2 as coordinating cell-cycle exit with differentiation of NSCs via direct actions on Ink4, Prox1, Notch1 and JAK/STAT.
format	article
author	Athanasios Stergiopoulos Panagiotis K. Politis
author_facet	Athanasios Stergiopoulos Panagiotis K. Politis
author_sort	Athanasios Stergiopoulos
title	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
title_short	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
title_full	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
title_fullStr	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
title_full_unstemmed	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development
title_sort	nuclear receptor nr5a2 controls neural stem cell fate decisions during development
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d2ea2f8f4bcf413f89c3f2c566fc5f26
work_keys_str_mv	AT athanasiosstergiopoulos nuclearreceptornr5a2controlsneuralstemcellfatedecisionsduringdevelopment AT panagiotiskpolitis nuclearreceptornr5a2controlsneuralstemcellfatedecisionsduringdevelopment
_version_	1718386504146878464

Nuclear receptor NR5A2 controls neural stem cell fate decisions during development

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