New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs

Due to the fast pace of development of spectroscopic research methods in the pharmaceutical expertise of drugs presented in the United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.), in this paper, we examined complex methods for the identification and preparation for analysis of po...

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Autores principales:	Yerbolat Orazbekuly, Gulzat Aitkaliyeva, Madeniyet Yelubay
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	tween-85 nmr ftir column chromatography sample preparation Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d2eba31a277249bca14f4e78b515aed9
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spelling	oai:doaj.org-article:d2eba31a277249bca14f4e78b515aed92021-11-15T06:08:47ZNew Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs2338-94272338-948610.22146/ijp.592https://doaj.org/article/d2eba31a277249bca14f4e78b515aed92020-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/592https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Due to the fast pace of development of spectroscopic research methods in the pharmaceutical expertise of drugs presented in the United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.), in this paper, we examined complex methods for the identification and preparation for analysis of polyethylene sorbitan trioleate. Two new systems were identified for purification of 98% polyoxyethylene sorbitan trioleate from organic impurities in column chromatography: acetonitrile 100% and acetonitrile/acetone 7.5/2.5. It was also revealed that a chamber with metallic iodine was the most suitable for selecting an eluent and controlling the cleaning by the TLC method. Proton NMR did not detect organic impurities. Identification of polyoxyethylene sorbitan trioleate was carried out on H1, C13, COSY, and IR spectra. These research methods are characterized by simplicity in sample preparation, the availability of reagents, the effectiveness of identification and quantification analyzes, and the efficiency in labor and material costsYerbolat OrazbekulyGulzat AitkaliyevaMadeniyet YelubayUniversitas Gadjah Madaarticletween-85nmrftircolumn chromatographysample preparationPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 181-186 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tween-85 nmr ftir column chromatography sample preparation Pharmacy and materia medica RS1-441
spellingShingle	tween-85 nmr ftir column chromatography sample preparation Pharmacy and materia medica RS1-441 Yerbolat Orazbekuly Gulzat Aitkaliyeva Madeniyet Yelubay New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
description	Due to the fast pace of development of spectroscopic research methods in the pharmaceutical expertise of drugs presented in the United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.), in this paper, we examined complex methods for the identification and preparation for analysis of polyethylene sorbitan trioleate. Two new systems were identified for purification of 98% polyoxyethylene sorbitan trioleate from organic impurities in column chromatography: acetonitrile 100% and acetonitrile/acetone 7.5/2.5. It was also revealed that a chamber with metallic iodine was the most suitable for selecting an eluent and controlling the cleaning by the TLC method. Proton NMR did not detect organic impurities. Identification of polyoxyethylene sorbitan trioleate was carried out on H1, C13, COSY, and IR spectra. These research methods are characterized by simplicity in sample preparation, the availability of reagents, the effectiveness of identification and quantification analyzes, and the efficiency in labor and material costs
format	article
author	Yerbolat Orazbekuly Gulzat Aitkaliyeva Madeniyet Yelubay
author_facet	Yerbolat Orazbekuly Gulzat Aitkaliyeva Madeniyet Yelubay
author_sort	Yerbolat Orazbekuly
title	New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
title_short	New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
title_full	New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
title_fullStr	New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
title_full_unstemmed	New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs
title_sort	new approaches to sample preparation and integrated spectroscopic methods for the identification of polioxyethylene triolate sorbitane for pharmaceutical examination of drugs
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/d2eba31a277249bca14f4e78b515aed9
work_keys_str_mv	AT yerbolatorazbekuly newapproachestosamplepreparationandintegratedspectroscopicmethodsfortheidentificationofpolioxyethylenetriolatesorbitaneforpharmaceuticalexaminationofdrugs AT gulzataitkaliyeva newapproachestosamplepreparationandintegratedspectroscopicmethodsfortheidentificationofpolioxyethylenetriolatesorbitaneforpharmaceuticalexaminationofdrugs AT madeniyetyelubay newapproachestosamplepreparationandintegratedspectroscopicmethodsfortheidentificationofpolioxyethylenetriolatesorbitaneforpharmaceuticalexaminationofdrugs
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New Approaches to Sample Preparation and Integrated Spectroscopic Methods for The Identification of Polioxyethylene Triolate Sorbitane for Pharmaceutical Examination of Drugs

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