Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting

Many genetic variants have been associated with complex congenital disorders, but their function is not always clear. Here, the authors develop a pipeline to functionally characterize such variants, and show potential roles for three SNPs in non-syndromic cleft lip and palate.

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Autores principales:	Huan Liu, Elizabeth J. Leslie, Jenna C. Carlson, Terri H. Beaty, Mary L. Marazita, Andrew C. Lidral, Robert A. Cornell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2ec248fe44d4a7987ee187d2090d430
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spelling	oai:doaj.org-article:d2ec248fe44d4a7987ee187d2090d4302021-12-02T14:43:00ZIdentification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting10.1038/ncomms147592041-1723https://doaj.org/article/d2ec248fe44d4a7987ee187d2090d4302017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14759https://doaj.org/toc/2041-1723Many genetic variants have been associated with complex congenital disorders, but their function is not always clear. Here, the authors develop a pipeline to functionally characterize such variants, and show potential roles for three SNPs in non-syndromic cleft lip and palate.Huan LiuElizabeth J. LeslieJenna C. CarlsonTerri H. BeatyMary L. MarazitaAndrew C. LidralRobert A. CornellNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Liu Elizabeth J. Leslie Jenna C. Carlson Terri H. Beaty Mary L. Marazita Andrew C. Lidral Robert A. Cornell Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
description	Many genetic variants have been associated with complex congenital disorders, but their function is not always clear. Here, the authors develop a pipeline to functionally characterize such variants, and show potential roles for three SNPs in non-syndromic cleft lip and palate.
format	article
author	Huan Liu Elizabeth J. Leslie Jenna C. Carlson Terri H. Beaty Mary L. Marazita Andrew C. Lidral Robert A. Cornell
author_facet	Huan Liu Elizabeth J. Leslie Jenna C. Carlson Terri H. Beaty Mary L. Marazita Andrew C. Lidral Robert A. Cornell
author_sort	Huan Liu
title	Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
title_short	Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
title_full	Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
title_fullStr	Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
title_full_unstemmed	Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
title_sort	identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2ec248fe44d4a7987ee187d2090d430
work_keys_str_mv	AT huanliu identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT elizabethjleslie identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT jennaccarlson identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT terrihbeaty identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT marylmarazita identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT andrewclidral identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting AT robertacornell identificationofcommonnoncodingvariantsat1p22thatarefunctionalfornonsyndromicorofacialclefting
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Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting

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