Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons

Abstract Spatial restriction of olfactory receptor (OR) gene expression in peripheral sense organs is a common phenomenon across species, suggesting that zonal OR expression somehow contributes to olfactory function. In zebrafish OR expression patterns reminiscent of zones occur as concentric domain...

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Autores principales:	Xalid Bayramli, Yiğit Kocagöz, Uğurcan Sakizli, Stefan H. Fuss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d2ece3c0979b489d9d1dd83746e2cee9
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spelling	oai:doaj.org-article:d2ece3c0979b489d9d1dd83746e2cee92021-12-02T12:32:57ZPatterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons10.1038/s41598-017-06041-12045-2322https://doaj.org/article/d2ece3c0979b489d9d1dd83746e2cee92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06041-1https://doaj.org/toc/2045-2322Abstract Spatial restriction of olfactory receptor (OR) gene expression in peripheral sense organs is a common phenomenon across species, suggesting that zonal OR expression somehow contributes to olfactory function. In zebrafish OR expression patterns reminiscent of zones occur as concentric domains with preferred diameters for different ORs. However, the function and the developmental origin of the pattern are unknown. Here we investigate olfactory sensory neuron (OSN) neurogenesis in the adult zebrafish olfactory epithelium (OE) to understand how the zonally organized OR pattern is established and maintained during the lifetime of the animal. We find that OSNs are generated from two discontinuous proliferation zones located at the central and peripheral edge of the sensory OE. OSNs turn on OR expression soon after they exit mitosis and invade the sensory tissue, approaching each other from both ends of the OE. Biased generation of OSN subpopulations at both neurogenic sites and elimination of OSNs along their route across the OE generates the impression of OR-specific expression domains. We formulated a simple mathematical model based on exact parameters derived from our analysis of OSN neurogenesis, which accurately generates OR-like distributions without the need to invoke molecular signals to pattern the OE.Xalid BayramliYiğit KocagözUğurcan SakizliStefan H. FussNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xalid Bayramli Yiğit Kocagöz Uğurcan Sakizli Stefan H. Fuss Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
description	Abstract Spatial restriction of olfactory receptor (OR) gene expression in peripheral sense organs is a common phenomenon across species, suggesting that zonal OR expression somehow contributes to olfactory function. In zebrafish OR expression patterns reminiscent of zones occur as concentric domains with preferred diameters for different ORs. However, the function and the developmental origin of the pattern are unknown. Here we investigate olfactory sensory neuron (OSN) neurogenesis in the adult zebrafish olfactory epithelium (OE) to understand how the zonally organized OR pattern is established and maintained during the lifetime of the animal. We find that OSNs are generated from two discontinuous proliferation zones located at the central and peripheral edge of the sensory OE. OSNs turn on OR expression soon after they exit mitosis and invade the sensory tissue, approaching each other from both ends of the OE. Biased generation of OSN subpopulations at both neurogenic sites and elimination of OSNs along their route across the OE generates the impression of OR-specific expression domains. We formulated a simple mathematical model based on exact parameters derived from our analysis of OSN neurogenesis, which accurately generates OR-like distributions without the need to invoke molecular signals to pattern the OE.
format	article
author	Xalid Bayramli Yiğit Kocagöz Uğurcan Sakizli Stefan H. Fuss
author_facet	Xalid Bayramli Yiğit Kocagöz Uğurcan Sakizli Stefan H. Fuss
author_sort	Xalid Bayramli
title	Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
title_short	Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
title_full	Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
title_fullStr	Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
title_full_unstemmed	Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons
title_sort	patterned arrangements of olfactory receptor gene expression in zebrafish are established by radial movement of specified olfactory sensory neurons
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2ece3c0979b489d9d1dd83746e2cee9
work_keys_str_mv	AT xalidbayramli patternedarrangementsofolfactoryreceptorgeneexpressioninzebrafishareestablishedbyradialmovementofspecifiedolfactorysensoryneurons AT yigitkocagoz patternedarrangementsofolfactoryreceptorgeneexpressioninzebrafishareestablishedbyradialmovementofspecifiedolfactorysensoryneurons AT ugurcansakizli patternedarrangementsofolfactoryreceptorgeneexpressioninzebrafishareestablishedbyradialmovementofspecifiedolfactorysensoryneurons AT stefanhfuss patternedarrangementsofolfactoryreceptorgeneexpressioninzebrafishareestablishedbyradialmovementofspecifiedolfactorysensoryneurons
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Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons

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