Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We u...

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Autores principales:	Agnieszka Barańska, Agata Błaszczuk, Wiesław Kanadys, Maria Malm, Katarzyna Drop, Małgorzata Polz-Dacewicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oral contraceptives breast cancer risk risk factors breast malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d2f078d01ffa453eb4bcd615f56b925a
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spelling	oai:doaj.org-article:d2f078d01ffa453eb4bcd615f56b925a2021-11-25T17:02:13ZOral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–202010.3390/cancers132256542072-6694https://doaj.org/article/d2f078d01ffa453eb4bcd615f56b925a2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5654https://doaj.org/toc/2072-6694To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, <i>p</i> = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.Agnieszka BarańskaAgata BłaszczukWiesław KanadysMaria MalmKatarzyna DropMałgorzata Polz-DacewiczMDPI AGarticleoral contraceptivesbreast cancerriskrisk factorsbreast malignanciesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5654, p 5654 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral contraceptives breast cancer risk risk factors breast malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	oral contraceptives breast cancer risk risk factors breast malignancies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Agnieszka Barańska Agata Błaszczuk Wiesław Kanadys Maria Malm Katarzyna Drop Małgorzata Polz-Dacewicz Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
description	To perform a meta-analysis of case-control studies that addressed the association between oral contraceptive pills (OC) use and breast cancer (BrCa), PubMED (MEDLINE), Embase, and the Cochrane Library were searched to identify case-control studies of OC and BrCa published between 2009 and 2020. We used the DerSimonian–Laird method to compute pooled odds ratios (ORs) and confidence intervals (CIs), and the Mantel–Haenszel test to assess the association between OC use and cancer. Forty-two studies were identified that met the inclusion criteria and we included a total of 110,580 women (30,778 into the BrCa group and 79,802 into the control group, of which 15,722 and 38,334 were using OC, respectively). The conducted meta-analysis showed that the use of OC was associated with a significantly increased risk of BrCa in general, OR = 1.15, 95% CI: 1.01 to 1.31, <i>p</i> = 0.0358. Regarding other risk factors for BrCa, we found that increased risk was associated significantly with early menarche, nulliparous, non-breastfeeding, older age at first parity, postmenopause, obesity, smoking, and family history of BrCa. Despite our conclusion that birth control pills increase the cancer risk being supported by extensive previous studies and meta-analyzes, further confirmation is required.
format	article
author	Agnieszka Barańska Agata Błaszczuk Wiesław Kanadys Maria Malm Katarzyna Drop Małgorzata Polz-Dacewicz
author_facet	Agnieszka Barańska Agata Błaszczuk Wiesław Kanadys Maria Malm Katarzyna Drop Małgorzata Polz-Dacewicz
author_sort	Agnieszka Barańska
title	Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
title_short	Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
title_full	Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
title_fullStr	Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
title_full_unstemmed	Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020
title_sort	oral contraceptive use and breast cancer risk assessment: a systematic review and meta-analysis of case-control studies, 2009–2020
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d2f078d01ffa453eb4bcd615f56b925a
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Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009–2020

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