TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer.

TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer.

In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which...

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Bibliographic Details
Main Authors: Ana Martinez-Canto, Adela Castillejo, Trinidad Mata-Balaguer, Maria-Isabel Castillejo, Eva Hernandez-Illan, Esperanza Irles, Victor Manuel Barbera, Cecilia Egoavil, Carla Guarinos, Cristina Alenda, Enrique Ochoa, Rafael Lazaro, Silvia Fajardo, Javier Lacueva, Rafael Calpena, Jose Luis Soto
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/d2f8a9a836814a7ea970a57da1705902
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