ATP activates bestrophin ion channels through direct interaction

Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

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Autores principales:	Yu Zhang, Alec Kittredge, Nancy Ward, Changyi Ji, Shoudeng Chen, Tingting Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a
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spelling	oai:doaj.org-article:d2fbb4e9fd0d4e02a648786cc5e5354a2021-12-02T14:39:22ZATP activates bestrophin ion channels through direct interaction10.1038/s41467-018-05616-42041-1723https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05616-4https://doaj.org/toc/2041-1723Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.Yu ZhangAlec KittredgeNancy WardChangyi JiShoudeng ChenTingting YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Zhang Alec Kittredge Nancy Ward Changyi Ji Shoudeng Chen Tingting Yang ATP activates bestrophin ion channels through direct interaction
description	Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.
format	article
author	Yu Zhang Alec Kittredge Nancy Ward Changyi Ji Shoudeng Chen Tingting Yang
author_facet	Yu Zhang Alec Kittredge Nancy Ward Changyi Ji Shoudeng Chen Tingting Yang
author_sort	Yu Zhang
title	ATP activates bestrophin ion channels through direct interaction
title_short	ATP activates bestrophin ion channels through direct interaction
title_full	ATP activates bestrophin ion channels through direct interaction
title_fullStr	ATP activates bestrophin ion channels through direct interaction
title_full_unstemmed	ATP activates bestrophin ion channels through direct interaction
title_sort	atp activates bestrophin ion channels through direct interaction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a
work_keys_str_mv	AT yuzhang atpactivatesbestrophinionchannelsthroughdirectinteraction AT aleckittredge atpactivatesbestrophinionchannelsthroughdirectinteraction AT nancyward atpactivatesbestrophinionchannelsthroughdirectinteraction AT changyiji atpactivatesbestrophinionchannelsthroughdirectinteraction AT shoudengchen atpactivatesbestrophinionchannelsthroughdirectinteraction AT tingtingyang atpactivatesbestrophinionchannelsthroughdirectinteraction
_version_	1718390682909933568

ATP activates bestrophin ion channels through direct interaction

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