ATP activates bestrophin ion channels through direct interaction

ATP activates bestrophin ion channels through direct interaction

Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

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Autores principales: Yu Zhang, Alec Kittredge, Nancy Ward, Changyi Ji, Shoudeng Chen, Tingting Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a
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