Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer

Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the ac...

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Autores principales:	Fátima Valdés-Mora, Cathryn M. Gould, Yolanda Colino-Sanguino, Wenjia Qu, Jenny Z. Song, Kylie M. Taylor, Fabian A. Buske, Aaron L. Statham, Shalima S. Nair, Nicola J. Armstrong, James G. Kench, Kenneth M. L. Lee, Lisa G. Horvath, Minru Qiu, Alexei Ilinykh, Nicole S. Yeo-Teh, David Gallego-Ortega, Clare Stirzaker, Susan J. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2ff8d2d6d19424694b455f94d09d58c
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spelling	oai:doaj.org-article:d2ff8d2d6d19424694b455f94d09d58c2021-12-02T14:40:48ZAcetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer10.1038/s41467-017-01393-82041-1723https://doaj.org/article/d2ff8d2d6d19424694b455f94d09d58c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01393-8https://doaj.org/toc/2041-1723Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the activity of specific enhancers of cancer-related genes.Fátima Valdés-MoraCathryn M. GouldYolanda Colino-SanguinoWenjia QuJenny Z. SongKylie M. TaylorFabian A. BuskeAaron L. StathamShalima S. NairNicola J. ArmstrongJames G. KenchKenneth M. L. LeeLisa G. HorvathMinru QiuAlexei IlinykhNicole S. Yeo-TehDavid Gallego-OrtegaClare StirzakerSusan J. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fátima Valdés-Mora Cathryn M. Gould Yolanda Colino-Sanguino Wenjia Qu Jenny Z. Song Kylie M. Taylor Fabian A. Buske Aaron L. Statham Shalima S. Nair Nicola J. Armstrong James G. Kench Kenneth M. L. Lee Lisa G. Horvath Minru Qiu Alexei Ilinykh Nicole S. Yeo-Teh David Gallego-Ortega Clare Stirzaker Susan J. Clark Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
description	Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the activity of specific enhancers of cancer-related genes.
format	article
author	Fátima Valdés-Mora Cathryn M. Gould Yolanda Colino-Sanguino Wenjia Qu Jenny Z. Song Kylie M. Taylor Fabian A. Buske Aaron L. Statham Shalima S. Nair Nicola J. Armstrong James G. Kench Kenneth M. L. Lee Lisa G. Horvath Minru Qiu Alexei Ilinykh Nicole S. Yeo-Teh David Gallego-Ortega Clare Stirzaker Susan J. Clark
author_facet	Fátima Valdés-Mora Cathryn M. Gould Yolanda Colino-Sanguino Wenjia Qu Jenny Z. Song Kylie M. Taylor Fabian A. Buske Aaron L. Statham Shalima S. Nair Nicola J. Armstrong James G. Kench Kenneth M. L. Lee Lisa G. Horvath Minru Qiu Alexei Ilinykh Nicole S. Yeo-Teh David Gallego-Ortega Clare Stirzaker Susan J. Clark
author_sort	Fátima Valdés-Mora
title	Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
title_short	Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
title_full	Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
title_fullStr	Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
title_full_unstemmed	Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
title_sort	acetylated histone variant h2a.z is involved in the activation of neo-enhancers in prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d2ff8d2d6d19424694b455f94d09d58c
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Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer

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