The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model

Background As a chronic autoimmune disease, rheumatoid arthritis (RA) is related to oxidative stress, which may lead to the occurrence and persistence of inflammation in RA. The purpose of this study is to evaluate the potential antioxidant effect of triptolide in collagen-induced arthritis (CIA) ra...

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Autores principales:	Guang-Min Yu, Li-Feng Zhou, Bi-Xia Zeng, Jing-Jun Huang, Xiao-jun She
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	triptolide rheumatoid arthritis rat collagen induced arthritis local oxidative stress systemic oxidative stress bone destruction relative weight of organ Pathology RB1-214 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d3075bc4cedd47ce85381a5f4ebf420a
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spelling	oai:doaj.org-article:d3075bc4cedd47ce85381a5f4ebf420a2021-11-26T11:19:47ZThe antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model1351-00021743-292810.1080/13510002.2021.2004047https://doaj.org/article/d3075bc4cedd47ce85381a5f4ebf420a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13510002.2021.2004047https://doaj.org/toc/1351-0002https://doaj.org/toc/1743-2928Background As a chronic autoimmune disease, rheumatoid arthritis (RA) is related to oxidative stress, which may lead to the occurrence and persistence of inflammation in RA. The purpose of this study is to evaluate the potential antioxidant effect of triptolide in collagen-induced arthritis (CIA) rat model. Methods We examined the severity of arthritis, levels of local and systemic oxidative stress, periarticular bone erosion and weight of organs in CIA rats treated with triptolide. Results We found that triptolide decreased the paw thickness and clinical arthritis score, significantly. The mRNA expression and activity of myeloperoxidase and inducible nitric oxide synthase were remarkably decreased in the paws of the CIA rats after triptolide treatment. Triptolide significantly inhibited the levels of nitrite and nitrate in serum, as well as the urinary level of dityrosine. Triptolide treatment also markedly increased bone volume of tibia, but suppressed epiphyseal plate thickness of both femur and tibia. In addition, there was no significant difference in the weight of organs after the therapy, except decreased spleen weight. Conclusions These results suggested that the local and systemic oxidative stress was enhanced in the CIA rats and the therapeutic dose of triptolide had a definite antioxidant effect.Guang-Min YuLi-Feng ZhouBi-Xia ZengJing-Jun HuangXiao-jun SheTaylor & Francis Grouparticletriptoliderheumatoid arthritisratcollagen induced arthritislocal oxidative stresssystemic oxidative stressbone destructionrelative weight of organPathologyRB1-214Biology (General)QH301-705.5ENRedox Report, Vol 26, Iss 1, Pp 197-202 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	triptolide rheumatoid arthritis rat collagen induced arthritis local oxidative stress systemic oxidative stress bone destruction relative weight of organ Pathology RB1-214 Biology (General) QH301-705.5
spellingShingle	triptolide rheumatoid arthritis rat collagen induced arthritis local oxidative stress systemic oxidative stress bone destruction relative weight of organ Pathology RB1-214 Biology (General) QH301-705.5 Guang-Min Yu Li-Feng Zhou Bi-Xia Zeng Jing-Jun Huang Xiao-jun She The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
description	Background As a chronic autoimmune disease, rheumatoid arthritis (RA) is related to oxidative stress, which may lead to the occurrence and persistence of inflammation in RA. The purpose of this study is to evaluate the potential antioxidant effect of triptolide in collagen-induced arthritis (CIA) rat model. Methods We examined the severity of arthritis, levels of local and systemic oxidative stress, periarticular bone erosion and weight of organs in CIA rats treated with triptolide. Results We found that triptolide decreased the paw thickness and clinical arthritis score, significantly. The mRNA expression and activity of myeloperoxidase and inducible nitric oxide synthase were remarkably decreased in the paws of the CIA rats after triptolide treatment. Triptolide significantly inhibited the levels of nitrite and nitrate in serum, as well as the urinary level of dityrosine. Triptolide treatment also markedly increased bone volume of tibia, but suppressed epiphyseal plate thickness of both femur and tibia. In addition, there was no significant difference in the weight of organs after the therapy, except decreased spleen weight. Conclusions These results suggested that the local and systemic oxidative stress was enhanced in the CIA rats and the therapeutic dose of triptolide had a definite antioxidant effect.
format	article
author	Guang-Min Yu Li-Feng Zhou Bi-Xia Zeng Jing-Jun Huang Xiao-jun She
author_facet	Guang-Min Yu Li-Feng Zhou Bi-Xia Zeng Jing-Jun Huang Xiao-jun She
author_sort	Guang-Min Yu
title	The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
title_short	The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
title_full	The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
title_fullStr	The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
title_full_unstemmed	The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
title_sort	antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d3075bc4cedd47ce85381a5f4ebf420a
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The antioxidant effect of triptolide contributes to the therapy in a collagen-induced arthritis rat model

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