Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neu...

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Autores principales:	Bart C. Jongbloets, Suzanne Lemstra, Roberta Schellino, Mark H. Broekhoven, Jyoti Parkash, Anita J. C. G. M. Hellemons, Tianyi Mao, Paolo Giacobini, Henriette van Praag, Silvia De Marchis, Geert M. J. Ramakers, R. Jeroen Pasterkamp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d30daa3df5364f93beb8a981d0a1cc8e
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spelling	oai:doaj.org-article:d30daa3df5364f93beb8a981d0a1cc8e2021-12-02T14:42:17ZStage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors10.1038/ncomms146662041-1723https://doaj.org/article/d30daa3df5364f93beb8a981d0a1cc8e2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14666https://doaj.org/toc/2041-1723The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.Bart C. JongbloetsSuzanne LemstraRoberta SchellinoMark H. BroekhovenJyoti ParkashAnita J. C. G. M. HellemonsTianyi MaoPaolo GiacobiniHenriette van PraagSilvia De MarchisGeert M. J. RamakersR. Jeroen PasterkampNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bart C. Jongbloets Suzanne Lemstra Roberta Schellino Mark H. Broekhoven Jyoti Parkash Anita J. C. G. M. Hellemons Tianyi Mao Paolo Giacobini Henriette van Praag Silvia De Marchis Geert M. J. Ramakers R. Jeroen Pasterkamp Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
description	The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.
format	article
author	Bart C. Jongbloets Suzanne Lemstra Roberta Schellino Mark H. Broekhoven Jyoti Parkash Anita J. C. G. M. Hellemons Tianyi Mao Paolo Giacobini Henriette van Praag Silvia De Marchis Geert M. J. Ramakers R. Jeroen Pasterkamp
author_facet	Bart C. Jongbloets Suzanne Lemstra Roberta Schellino Mark H. Broekhoven Jyoti Parkash Anita J. C. G. M. Hellemons Tianyi Mao Paolo Giacobini Henriette van Praag Silvia De Marchis Geert M. J. Ramakers R. Jeroen Pasterkamp
author_sort	Bart C. Jongbloets
title	Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
title_short	Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
title_full	Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
title_fullStr	Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
title_full_unstemmed	Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
title_sort	stage-specific functions of semaphorin7a during adult hippocampal neurogenesis rely on distinct receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d30daa3df5364f93beb8a981d0a1cc8e
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Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

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