EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS

Objective: To study the histomorphological effects of platelet rich plasma infusion on number of chondrocytes in articular cartilage of monosodium iodoacetate induced osteoarthritic rat knee model. Study Design: Experimental study. Place and Duration of Study: Department of Anatomy, Army Medic...

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Autores principales:	Rafia Asjid, Tehmina Qamar, Tayyaba Faisal, Faiza Umbreen, Saima Sohail, Summaya Bashir, Khadija Qamar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	chondrocyte mono iodoacetate osteoarthritis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d31303955a004511aba9f6cc70ee105d
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spelling	oai:doaj.org-article:d31303955a004511aba9f6cc70ee105d2021-11-12T03:01:54ZEFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS0030-96482411-8842https://doaj.org/article/d31303955a004511aba9f6cc70ee105d2019-06-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3022/2260https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To study the histomorphological effects of platelet rich plasma infusion on number of chondrocytes in articular cartilage of monosodium iodoacetate induced osteoarthritic rat knee model. Study Design: Experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi from March to May 2018. Methodology: Thirty two healthy adult male rats of 3-4 months of age weighing 200-300 gm were taken. Animals were divided into two groups A and B as control and experimental with 8 and 24 animals respectively. Group B was further subdivided into B1, B2 and B3 with 8 animals in each group. All rats were injected with 50 μl of monoiodoacetate solution in the right knee. Group B1 along with group A was sacrificed on day 14 for establishing the presence of histological features of osteoarthritis (OA). Group B2 was injected with single dose of platelet rich plasma on day 18. Group B3 was not given any treatment. All animals were sacrificed 4 weeks after the injection of platelet rich plasma (PRP) in group B2. Number of chondrocytes was observed. Results were analyzed using SPSS v 21. Results: Significant decrease in chondrocyte count was noted in group B3 as compared to group B2 in which PRP therapy was given. Conclusion: Platelet rich plasma infusion prevented chondrocyte apoptosis in the treated group as compared to the untreated group.Rafia AsjidTehmina QamarTayyaba FaisalFaiza UmbreenSaima SohailSummaya BashirKhadija QamarArmy Medical College Rawalpindiarticlechondrocytemono iodoacetateosteoarthritisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 3, Pp 534-539 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	chondrocyte mono iodoacetate osteoarthritis Medicine R Medicine (General) R5-920
spellingShingle	chondrocyte mono iodoacetate osteoarthritis Medicine R Medicine (General) R5-920 Rafia Asjid Tehmina Qamar Tayyaba Faisal Faiza Umbreen Saima Sohail Summaya Bashir Khadija Qamar EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
description	Objective: To study the histomorphological effects of platelet rich plasma infusion on number of chondrocytes in articular cartilage of monosodium iodoacetate induced osteoarthritic rat knee model. Study Design: Experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi from March to May 2018. Methodology: Thirty two healthy adult male rats of 3-4 months of age weighing 200-300 gm were taken. Animals were divided into two groups A and B as control and experimental with 8 and 24 animals respectively. Group B was further subdivided into B1, B2 and B3 with 8 animals in each group. All rats were injected with 50 μl of monoiodoacetate solution in the right knee. Group B1 along with group A was sacrificed on day 14 for establishing the presence of histological features of osteoarthritis (OA). Group B2 was injected with single dose of platelet rich plasma on day 18. Group B3 was not given any treatment. All animals were sacrificed 4 weeks after the injection of platelet rich plasma (PRP) in group B2. Number of chondrocytes was observed. Results were analyzed using SPSS v 21. Results: Significant decrease in chondrocyte count was noted in group B3 as compared to group B2 in which PRP therapy was given. Conclusion: Platelet rich plasma infusion prevented chondrocyte apoptosis in the treated group as compared to the untreated group.
format	article
author	Rafia Asjid Tehmina Qamar Tayyaba Faisal Faiza Umbreen Saima Sohail Summaya Bashir Khadija Qamar
author_facet	Rafia Asjid Tehmina Qamar Tayyaba Faisal Faiza Umbreen Saima Sohail Summaya Bashir Khadija Qamar
author_sort	Rafia Asjid
title	EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
title_short	EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
title_full	EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
title_fullStr	EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
title_full_unstemmed	EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
title_sort	effect of platelet rich plasma on chondrocyte number in chemically induced animal model of osteoarthritis
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/d31303955a004511aba9f6cc70ee105d
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_version_	1718431318611591168

EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS

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