GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN

Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N...

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Autores principales:	D. A. Tarbaeva, T. E. Belokrinitskaya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	hla gene polymorphism hemostasis hla drb1 severe influenza a(h1n1) pdm2009 pregnancy Science Q
Acceso en línea:	https://doaj.org/article/d3235669765d459aa964ba8dace2fad8
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spelling	oai:doaj.org-article:d3235669765d459aa964ba8dace2fad82021-11-23T06:14:33ZGENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN2541-94202587-9596https://doaj.org/article/d3235669765d459aa964ba8dace2fad82015-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/124https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N1)pdm09 during pregnancy. Significant association between heterozygotes genotype F7: 0976G/A and complicated forms of influenza was found (OR = 1,5). Mutant homozygotes with PAI-1:675 4G/4G genotype also had high risk of severe complicated influenza A(H1N1) (OR = 1,5). Genotypes HLA DRB10715 and DRB11616 were associated with complicated influenza. We assume, that сombined F7:0976GA, PAI-1:6754G4G and HLA DRB10715, 1616, DRB10101 genotypes may be genetic predictor of severe complicated flu А(H1N1)pdm09 in pregnancy.D. A. TarbaevaT. E. BelokrinitskayaScientific Сentre for Family Health and Human Reproduction Problemsarticlehlagene polymorphismhemostasishla drb1severe influenza a(h1n1) pdm2009pregnancyScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 100-106 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	hla gene polymorphism hemostasis hla drb1 severe influenza a(h1n1) pdm2009 pregnancy Science Q
spellingShingle	hla gene polymorphism hemostasis hla drb1 severe influenza a(h1n1) pdm2009 pregnancy Science Q D. A. Tarbaeva T. E. Belokrinitskaya GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
description	Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N1)pdm09 during pregnancy. Significant association between heterozygotes genotype F7: 0976G/A and complicated forms of influenza was found (OR = 1,5). Mutant homozygotes with PAI-1:675 4G/4G genotype also had high risk of severe complicated influenza A(H1N1) (OR = 1,5). Genotypes HLA DRB10715 and DRB11616 were associated with complicated influenza. We assume, that сombined F7:0976GA, PAI-1:6754G4G and HLA DRB10715, 1616, DRB10101 genotypes may be genetic predictor of severe complicated flu А(H1N1)pdm09 in pregnancy.
format	article
author	D. A. Tarbaeva T. E. Belokrinitskaya
author_facet	D. A. Tarbaeva T. E. Belokrinitskaya
author_sort	D. A. Tarbaeva
title	GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
title_short	GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
title_full	GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
title_fullStr	GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
title_full_unstemmed	GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN
title_sort	genetic predictors of severe complicated influenza a(h1 n1) in pregnant women
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/d3235669765d459aa964ba8dace2fad8
work_keys_str_mv	AT datarbaeva geneticpredictorsofseverecomplicatedinfluenzaah1n1inpregnantwomen AT tebelokrinitskaya geneticpredictorsofseverecomplicatedinfluenzaah1n1inpregnantwomen
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GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN

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