The ACTN3 R577X polymorphism across three groups of elite male European athletes.
The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons diffic...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d324064009c0413f8f6612a64c65af11 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d324064009c0413f8f6612a64c65af11 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d324064009c0413f8f6612a64c65af112021-11-18T07:08:34ZThe ACTN3 R577X polymorphism across three groups of elite male European athletes.1932-620310.1371/journal.pone.0043132https://doaj.org/article/d324064009c0413f8f6612a64c65af112012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22916217/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34-0.48; P=0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07-3.31; P=0.028). In endurance athletes, the OR of a "world-class" competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08-12.94; P=0.038) compared with those of a lower ("national") competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance.Nir EynonJonatan R RuizPedro FemiaVladimir P PushkarevPawel CieszczykAgnieszka Maciejewska-KarlowskaMarek SawczukDmitry A DyatlovEvgeny V LekontsevLeonid M KulikovRuth BirkDavid J BishopAlejandro LuciaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43132 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Nir Eynon Jonatan R Ruiz Pedro Femia Vladimir P Pushkarev Pawel Cieszczyk Agnieszka Maciejewska-Karlowska Marek Sawczuk Dmitry A Dyatlov Evgeny V Lekontsev Leonid M Kulikov Ruth Birk David J Bishop Alejandro Lucia The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| description |
The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34-0.48; P=0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07-3.31; P=0.028). In endurance athletes, the OR of a "world-class" competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08-12.94; P=0.038) compared with those of a lower ("national") competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance. |
| format |
article |
| author |
Nir Eynon Jonatan R Ruiz Pedro Femia Vladimir P Pushkarev Pawel Cieszczyk Agnieszka Maciejewska-Karlowska Marek Sawczuk Dmitry A Dyatlov Evgeny V Lekontsev Leonid M Kulikov Ruth Birk David J Bishop Alejandro Lucia |
| author_facet |
Nir Eynon Jonatan R Ruiz Pedro Femia Vladimir P Pushkarev Pawel Cieszczyk Agnieszka Maciejewska-Karlowska Marek Sawczuk Dmitry A Dyatlov Evgeny V Lekontsev Leonid M Kulikov Ruth Birk David J Bishop Alejandro Lucia |
| author_sort |
Nir Eynon |
| title |
The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| title_short |
The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| title_full |
The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| title_fullStr |
The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| title_full_unstemmed |
The ACTN3 R577X polymorphism across three groups of elite male European athletes. |
| title_sort |
actn3 r577x polymorphism across three groups of elite male european athletes. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/d324064009c0413f8f6612a64c65af11 |
| work_keys_str_mv |
AT nireynon theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT jonatanrruiz theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT pedrofemia theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT vladimirppushkarev theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT pawelcieszczyk theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT agnieszkamaciejewskakarlowska theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT mareksawczuk theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT dmitryadyatlov theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT evgenyvlekontsev theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT leonidmkulikov theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT ruthbirk theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT davidjbishop theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT alejandrolucia theactn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT nireynon actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT jonatanrruiz actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT pedrofemia actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT vladimirppushkarev actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT pawelcieszczyk actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT agnieszkamaciejewskakarlowska actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT mareksawczuk actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT dmitryadyatlov actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT evgenyvlekontsev actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT leonidmkulikov actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT ruthbirk actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT davidjbishop actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes AT alejandrolucia actn3r577xpolymorphismacrossthreegroupsofelitemaleeuropeanathletes |
| _version_ |
1718423884131205120 |