Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy

Radiotherapy (RT) is a major modality of postoperative treatment in breast cancer. The maximal standardized value (SUVmax) is 18FDG-PET/CT derived parameter that reported to be a valuable prognostic factor in cancer patients. Herein, we aimed to identify a prognostic gene signature associated with g...

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Autores principales:	Jin Meng, Emmanuel Deshayes, Li Zhang, Wei Shi, Xiaomeng Zhang, Xingxing Chen, Xin Mei, Jinli Ma, Yizhou Jiang, Jiong Wu, Zhimin Shao, Xiaoli Yu, Zhaozhi Yang, Xiaomao Guo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	breast cancer radiotherapy FDG uptake gene signature immunosuppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d3255fe1958849e4a8702e05732e7e46
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spelling	oai:doaj.org-article:d3255fe1958849e4a8702e05732e7e462021-11-14T04:34:25ZPrognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy2372-770510.1016/j.omto.2021.10.008https://doaj.org/article/d3255fe1958849e4a8702e05732e7e462021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2372770521001455https://doaj.org/toc/2372-7705Radiotherapy (RT) is a major modality of postoperative treatment in breast cancer. The maximal standardized value (SUVmax) is 18FDG-PET/CT derived parameter that reported to be a valuable prognostic factor in cancer patients. Herein, we aimed to identify a prognostic gene signature associated with glucose uptake for breast cancer patients after RT by leveraging the mRNA expression profiling on public datasets. The glucose uptake signature was constructed using the single sample gene set enrichment analysis (ssGSEA) algorithm and evaluated in GSE21217 where SUVmax value was measured by PET-CT directly. The prognostic value was validated in three post-RT breast cancer cohorts (GSE103744, NKI, and FUSCC databases). The patients were stratified into glucose uptake signature score-high and low groups. Patients with a higher score had worse survival than those with a lower score. Mechanistically, the glucose uptake signature was calculated in each cell type of a single-cell RNA-seq database from five breast cancer patients. Glucose uptake signature score was significantly elevated in the malignant epithelial cells compared with normal ones. The immunosuppression markers including PDCD1, TIGIT, LAG3, and HAVCR2 were significantly upregulated in the T cells bearing a high glucose uptake signature score. Collectively, our results demonstrated the potential prognostic value of a glucose uptake signature in the post-RT breast cancer patients.Jin MengEmmanuel DeshayesLi ZhangWei ShiXiaomeng ZhangXingxing ChenXin MeiJinli MaYizhou JiangJiong WuZhimin ShaoXiaoli YuZhaozhi YangXiaomao GuoElsevierarticlebreast cancerradiotherapyFDG uptakegene signatureimmunosuppressionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Therapy: Oncolytics, Vol 23, Iss , Pp 412-419 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer radiotherapy FDG uptake gene signature immunosuppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer radiotherapy FDG uptake gene signature immunosuppression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jin Meng Emmanuel Deshayes Li Zhang Wei Shi Xiaomeng Zhang Xingxing Chen Xin Mei Jinli Ma Yizhou Jiang Jiong Wu Zhimin Shao Xiaoli Yu Zhaozhi Yang Xiaomao Guo Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
description	Radiotherapy (RT) is a major modality of postoperative treatment in breast cancer. The maximal standardized value (SUVmax) is 18FDG-PET/CT derived parameter that reported to be a valuable prognostic factor in cancer patients. Herein, we aimed to identify a prognostic gene signature associated with glucose uptake for breast cancer patients after RT by leveraging the mRNA expression profiling on public datasets. The glucose uptake signature was constructed using the single sample gene set enrichment analysis (ssGSEA) algorithm and evaluated in GSE21217 where SUVmax value was measured by PET-CT directly. The prognostic value was validated in three post-RT breast cancer cohorts (GSE103744, NKI, and FUSCC databases). The patients were stratified into glucose uptake signature score-high and low groups. Patients with a higher score had worse survival than those with a lower score. Mechanistically, the glucose uptake signature was calculated in each cell type of a single-cell RNA-seq database from five breast cancer patients. Glucose uptake signature score was significantly elevated in the malignant epithelial cells compared with normal ones. The immunosuppression markers including PDCD1, TIGIT, LAG3, and HAVCR2 were significantly upregulated in the T cells bearing a high glucose uptake signature score. Collectively, our results demonstrated the potential prognostic value of a glucose uptake signature in the post-RT breast cancer patients.
format	article
author	Jin Meng Emmanuel Deshayes Li Zhang Wei Shi Xiaomeng Zhang Xingxing Chen Xin Mei Jinli Ma Yizhou Jiang Jiong Wu Zhimin Shao Xiaoli Yu Zhaozhi Yang Xiaomao Guo
author_facet	Jin Meng Emmanuel Deshayes Li Zhang Wei Shi Xiaomeng Zhang Xingxing Chen Xin Mei Jinli Ma Yizhou Jiang Jiong Wu Zhimin Shao Xiaoli Yu Zhaozhi Yang Xiaomao Guo
author_sort	Jin Meng
title	Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
title_short	Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
title_full	Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
title_fullStr	Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
title_full_unstemmed	Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy
title_sort	prognostic value of metabolic signature on 18f-fdguptake in breast cancer patients after radiotherapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d3255fe1958849e4a8702e05732e7e46
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Prognostic value of metabolic signature on 18F-FDGuptake in breast cancer patients after radiotherapy

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