Reprogramming the immunological microenvironment through radiation and targeting Axl

Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhances cytokine release promoting a suppressive myeloid...

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Autores principales:	Todd A. Aguilera, Marjan Rafat, Laura Castellini, Hussein Shehade, Mihalis S. Kariolis, Angela Bik-Yu Hui, Henning Stehr, Rie von Eyben, Dadi Jiang, Lesley G. Ellies, Albert C. Koong, Maximilian Diehn, Erinn B. Rankin, Edward E. Graves, Amato J. Giaccia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c
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spelling	oai:doaj.org-article:d32eb98fd69f4bdf897a2cd00a59903c2021-12-02T17:31:19ZReprogramming the immunological microenvironment through radiation and targeting Axl10.1038/ncomms138982041-1723https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13898https://doaj.org/toc/2041-1723Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhances cytokine release promoting a suppressive myeloid microenvironment.Todd A. AguileraMarjan RafatLaura CastelliniHussein ShehadeMihalis S. KariolisAngela Bik-Yu HuiHenning StehrRie von EybenDadi JiangLesley G. ElliesAlbert C. KoongMaximilian DiehnErinn B. RankinEdward E. GravesAmato J. GiacciaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Todd A. Aguilera Marjan Rafat Laura Castellini Hussein Shehade Mihalis S. Kariolis Angela Bik-Yu Hui Henning Stehr Rie von Eyben Dadi Jiang Lesley G. Ellies Albert C. Koong Maximilian Diehn Erinn B. Rankin Edward E. Graves Amato J. Giaccia Reprogramming the immunological microenvironment through radiation and targeting Axl
description	Radiotherapy can enhance the antitumour immune response. Here, the authors show that resistance to radiation in breast cancer cells can be due to Axl expression that suppresses antigen presentation though MHCI, promotes NF-κB signalling, and enhances cytokine release promoting a suppressive myeloid microenvironment.
format	article
author	Todd A. Aguilera Marjan Rafat Laura Castellini Hussein Shehade Mihalis S. Kariolis Angela Bik-Yu Hui Henning Stehr Rie von Eyben Dadi Jiang Lesley G. Ellies Albert C. Koong Maximilian Diehn Erinn B. Rankin Edward E. Graves Amato J. Giaccia
author_facet	Todd A. Aguilera Marjan Rafat Laura Castellini Hussein Shehade Mihalis S. Kariolis Angela Bik-Yu Hui Henning Stehr Rie von Eyben Dadi Jiang Lesley G. Ellies Albert C. Koong Maximilian Diehn Erinn B. Rankin Edward E. Graves Amato J. Giaccia
author_sort	Todd A. Aguilera
title	Reprogramming the immunological microenvironment through radiation and targeting Axl
title_short	Reprogramming the immunological microenvironment through radiation and targeting Axl
title_full	Reprogramming the immunological microenvironment through radiation and targeting Axl
title_fullStr	Reprogramming the immunological microenvironment through radiation and targeting Axl
title_full_unstemmed	Reprogramming the immunological microenvironment through radiation and targeting Axl
title_sort	reprogramming the immunological microenvironment through radiation and targeting axl
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d32eb98fd69f4bdf897a2cd00a59903c
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Reprogramming the immunological microenvironment through radiation and targeting Axl

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