Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis

Harold Merle,1 Stéphane Olindo,2 Séverine Jeannin,2 Rabih Hage,1 Angélique Donnio,1 Raymond Richer,1 Philippe Cabre2 1Service d'Ophtalmologie, 2Service de Neurologie, Centre Hospitalier Universitaire de Fort de France, Fort-de-France, Martinique, France Purpo...

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Autores principales:	Merle H, Olindo S, Jeannin S, Hage R, Donnio A, Richer R, Cabre P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d32ecba1a77e4a2c8877860bd0bfbcae
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spelling	oai:doaj.org-article:d32ecba1a77e4a2c8877860bd0bfbcae2021-12-02T01:30:27ZVisual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis1177-54671177-5483https://doaj.org/article/d32ecba1a77e4a2c8877860bd0bfbcae2013-06-01T00:00:00Zhttp://www.dovepress.com/visual-field-characteristics-in-neuromyelitis-optica-in-absence-of-and-a13315https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Harold Merle,1 Stéphane Olindo,2 Séverine Jeannin,2 Rabih Hage,1 Angélique Donnio,1 Raymond Richer,1 Philippe Cabre2 1Service d'Ophtalmologie, 2Service de Neurologie, Centre Hospitalier Universitaire de Fort de France, Fort-de-France, Martinique, France Purpose: Optic neuritis (ON) observed during neuromyelitis optica (NMO) is in most cases very severe and with poor prognosis. This study's objective was to analyze visual field (VF) abnormalities observed in the absence of ON and post-ON episode. Methods: Twenty-seven cases of both NMO and multiple sclerosis (MS) were selected. Thorough ophthalmologic exam was performed at least 6 months post-ON attack. The VF was collected using the Humphrey 750 perimeter. We used the central threshold tests 24-2 with FASTPAC strategy. The abnormalities were categorized based on the Optic Neuritis Treatment Trial classification. Results: After one ON, 40% of the NMO group's eyes showed total VF loss (P = 0.01), 21% showed abnormalities of neurologic aspect, and 27% showed fascicular abnormalities of which 12% were altitudinal. Given the total VF loss, the positive predictive value in favor of an NMO was 92.8% and the negative predictive value was 47.3%. Conclusion: Alterations of the VF during the NMO differ from those observed in the course of the MS. One ON, blinding from the first attack, must call to mind an NMO. The altitudinal deficits point to a vascular mechanism. Keywords: optic neuritis, visual field, neuromyelitis optica, multiple sclerosisMerle HOlindo SJeannin SHage RDonnio ARicher RCabre PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1145-1153 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Merle H Olindo S Jeannin S Hage R Donnio A Richer R Cabre P Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
description	Harold Merle,1 Stéphane Olindo,2 Séverine Jeannin,2 Rabih Hage,1 Angélique Donnio,1 Raymond Richer,1 Philippe Cabre2 1Service d'Ophtalmologie, 2Service de Neurologie, Centre Hospitalier Universitaire de Fort de France, Fort-de-France, Martinique, France Purpose: Optic neuritis (ON) observed during neuromyelitis optica (NMO) is in most cases very severe and with poor prognosis. This study's objective was to analyze visual field (VF) abnormalities observed in the absence of ON and post-ON episode. Methods: Twenty-seven cases of both NMO and multiple sclerosis (MS) were selected. Thorough ophthalmologic exam was performed at least 6 months post-ON attack. The VF was collected using the Humphrey 750 perimeter. We used the central threshold tests 24-2 with FASTPAC strategy. The abnormalities were categorized based on the Optic Neuritis Treatment Trial classification. Results: After one ON, 40% of the NMO group's eyes showed total VF loss (P = 0.01), 21% showed abnormalities of neurologic aspect, and 27% showed fascicular abnormalities of which 12% were altitudinal. Given the total VF loss, the positive predictive value in favor of an NMO was 92.8% and the negative predictive value was 47.3%. Conclusion: Alterations of the VF during the NMO differ from those observed in the course of the MS. One ON, blinding from the first attack, must call to mind an NMO. The altitudinal deficits point to a vascular mechanism. Keywords: optic neuritis, visual field, neuromyelitis optica, multiple sclerosis
format	article
author	Merle H Olindo S Jeannin S Hage R Donnio A Richer R Cabre P
author_facet	Merle H Olindo S Jeannin S Hage R Donnio A Richer R Cabre P
author_sort	Merle H
title	Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
title_short	Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
title_full	Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
title_fullStr	Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
title_full_unstemmed	Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
title_sort	visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d32ecba1a77e4a2c8877860bd0bfbcae
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_version_	1718403042864267264

Visual field characteristics in neuromyelitis optica in absence of and after one episode of optic neuritis

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