Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila

Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.

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Autores principales: Liang Li, Zhan Ding, Ting-Lin Pang, Bei Zhang, Chen-Hui Li, An-Min Liang, Yu-Ru Wang, Yu Zhou, Yu-Jie Fan, Yong-Zhen Xu
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef2
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spelling oai:doaj.org-article:d3335744b91b46fb96bb2443ca7deef22021-12-02T15:39:21ZDefective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila10.1038/s41467-020-19451-z2041-1723https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19451-zhttps://doaj.org/toc/2041-1723Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.Liang LiZhan DingTing-Lin PangBei ZhangChen-Hui LiAn-Min LiangYu-Ru WangYu ZhouYu-Jie FanYong-Zhen XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Liang Li
Zhan Ding
Ting-Lin Pang
Bei Zhang
Chen-Hui Li
An-Min Liang
Yu-Ru Wang
Yu Zhou
Yu-Jie Fan
Yong-Zhen Xu
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
description Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.
format article
author Liang Li
Zhan Ding
Ting-Lin Pang
Bei Zhang
Chen-Hui Li
An-Min Liang
Yu-Ru Wang
Yu Zhou
Yu-Jie Fan
Yong-Zhen Xu
author_facet Liang Li
Zhan Ding
Ting-Lin Pang
Bei Zhang
Chen-Hui Li
An-Min Liang
Yu-Ru Wang
Yu Zhou
Yu-Jie Fan
Yong-Zhen Xu
author_sort Liang Li
title Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
title_short Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
title_full Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
title_fullStr Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
title_full_unstemmed Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
title_sort defective minor spliceosomes induce sma-associated phenotypes through sensitive intron-containing neural genes in drosophila
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef2
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