Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila
Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.
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2020
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oai:doaj.org-article:d3335744b91b46fb96bb2443ca7deef22021-12-02T15:39:21ZDefective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila10.1038/s41467-020-19451-z2041-1723https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef22020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19451-zhttps://doaj.org/toc/2041-1723Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes.Liang LiZhan DingTing-Lin PangBei ZhangChen-Hui LiAn-Min LiangYu-Ru WangYu ZhouYu-Jie FanYong-Zhen XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Liang Li Zhan Ding Ting-Lin Pang Bei Zhang Chen-Hui Li An-Min Liang Yu-Ru Wang Yu Zhou Yu-Jie Fan Yong-Zhen Xu Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
description |
Spinal muscular atrophy (SMA) is associated with minor splicing-related defects. Here the authors develop Drosophila models with minor spliceosomal-snRNA deletions, and demonstrate SMA-like phenotypes. |
format |
article |
author |
Liang Li Zhan Ding Ting-Lin Pang Bei Zhang Chen-Hui Li An-Min Liang Yu-Ru Wang Yu Zhou Yu-Jie Fan Yong-Zhen Xu |
author_facet |
Liang Li Zhan Ding Ting-Lin Pang Bei Zhang Chen-Hui Li An-Min Liang Yu-Ru Wang Yu Zhou Yu-Jie Fan Yong-Zhen Xu |
author_sort |
Liang Li |
title |
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
title_short |
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
title_full |
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
title_fullStr |
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
title_full_unstemmed |
Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila |
title_sort |
defective minor spliceosomes induce sma-associated phenotypes through sensitive intron-containing neural genes in drosophila |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/d3335744b91b46fb96bb2443ca7deef2 |
work_keys_str_mv |
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1718385960441348096 |