BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives oste...

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Autores principales:	Yingnan Geng, Huichuan Duan, Liang Xu, Nevin Witman, Bingqian Yan, Zheyuan Yu, Huijing Wang, Yao Tan, Liqin Lin, Dong Li, Shanshan Bai, Regina Fritsche-Danielson, Jie Yuan, Kenneth Chien, Min Wei, Wei Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d333b9fe3c4e40e28331a8e504c5dc91
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spelling	oai:doaj.org-article:d333b9fe3c4e40e28331a8e504c5dc912021-12-02T14:09:01ZBMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways10.1038/s42003-020-01606-92399-3642https://doaj.org/article/d333b9fe3c4e40e28331a8e504c5dc912021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01606-9https://doaj.org/toc/2399-3642Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.Yingnan GengHuichuan DuanLiang XuNevin WitmanBingqian YanZheyuan YuHuijing WangYao TanLiqin LinDong LiShanshan BaiRegina Fritsche-DanielsonJie YuanKenneth ChienMin WeiWei FuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
description	Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.
format	article
author	Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu
author_facet	Yingnan Geng Huichuan Duan Liang Xu Nevin Witman Bingqian Yan Zheyuan Yu Huijing Wang Yao Tan Liqin Lin Dong Li Shanshan Bai Regina Fritsche-Danielson Jie Yuan Kenneth Chien Min Wei Wei Fu
author_sort	Yingnan Geng
title	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
title_short	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
title_full	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
title_fullStr	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
title_full_unstemmed	BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
title_sort	bmp-2 and vegf-a modrnas in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d333b9fe3c4e40e28331a8e504c5dc91
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BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

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