BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives oste...

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Autores principales: Yingnan Geng, Huichuan Duan, Liang Xu, Nevin Witman, Bingqian Yan, Zheyuan Yu, Huijing Wang, Yao Tan, Liqin Lin, Dong Li, Shanshan Bai, Regina Fritsche-Danielson, Jie Yuan, Kenneth Chien, Min Wei, Wei Fu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/d333b9fe3c4e40e28331a8e504c5dc91
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