The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer
Abstract Comparison studies using histopathology as standard of reference enable a validation of the diagnostic performance of imaging methods. This study analysed (1) the impact of different image-histopathology co-registration pathways, (2) the impact of the applied data analysis method and (3) in...
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2021
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oai:doaj.org-article:d335af9679c14ca7889336d2160d5cae2021-12-02T11:36:36ZThe impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer10.1038/s41598-021-85028-52045-2322https://doaj.org/article/d335af9679c14ca7889336d2160d5cae2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85028-5https://doaj.org/toc/2045-2322Abstract Comparison studies using histopathology as standard of reference enable a validation of the diagnostic performance of imaging methods. This study analysed (1) the impact of different image-histopathology co-registration pathways, (2) the impact of the applied data analysis method and (3) intraindividually compared multiparametric magnet resonance tomography (mpMRI) and prostate specific membrane antigen positron emission tomography (PSMA-PET) by using the different approaches. Ten patients with primary PCa who underwent mpMRI and [18F]PSMA-1007 PET/CT followed by prostatectomy were prospectively enrolled. We demonstrate that the choice of the intermediate registration step [(1) via ex-vivo CT or (2) mpMRI] does not significantly affect the performance of the registration framework. Comparison of analysis methods revealed that methods using high spatial resolutions e.g. quadrant-based slice-by-slice analysis are beneficial for a differentiated analysis of performance, compared to methods with a lower resolution (segment-based analysis with 6 or 18 segments and lesions-based analysis). Furthermore, PSMA-PET outperformed mpMRI for intraprostatic PCa detection in terms of sensitivity (median %: 83–85 vs. 60–69, p < 0.04) with similar specificity (median %: 74–93.8 vs. 100) using both registration pathways. To conclude, the choice of an intermediate registration pathway does not significantly affect registration performance, analysis methods with high spatial resolution are preferable and PSMA-PET outperformed mpMRI in terms of sensitivity in our cohort.Constantinos ZamboglouMaria KramerSelina KieferPeter BronsertLara CeciAugust SigleWolfgang Schultze-SeemannCordula A. JilgTanja SpraveThomas F. FassbenderNils H. NicolayJuri RufMatthias BenndorfAnca L. GrosuSimon K. B. SpohnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Constantinos Zamboglou Maria Kramer Selina Kiefer Peter Bronsert Lara Ceci August Sigle Wolfgang Schultze-Seemann Cordula A. Jilg Tanja Sprave Thomas F. Fassbender Nils H. Nicolay Juri Ruf Matthias Benndorf Anca L. Grosu Simon K. B. Spohn The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| description |
Abstract Comparison studies using histopathology as standard of reference enable a validation of the diagnostic performance of imaging methods. This study analysed (1) the impact of different image-histopathology co-registration pathways, (2) the impact of the applied data analysis method and (3) intraindividually compared multiparametric magnet resonance tomography (mpMRI) and prostate specific membrane antigen positron emission tomography (PSMA-PET) by using the different approaches. Ten patients with primary PCa who underwent mpMRI and [18F]PSMA-1007 PET/CT followed by prostatectomy were prospectively enrolled. We demonstrate that the choice of the intermediate registration step [(1) via ex-vivo CT or (2) mpMRI] does not significantly affect the performance of the registration framework. Comparison of analysis methods revealed that methods using high spatial resolutions e.g. quadrant-based slice-by-slice analysis are beneficial for a differentiated analysis of performance, compared to methods with a lower resolution (segment-based analysis with 6 or 18 segments and lesions-based analysis). Furthermore, PSMA-PET outperformed mpMRI for intraprostatic PCa detection in terms of sensitivity (median %: 83–85 vs. 60–69, p < 0.04) with similar specificity (median %: 74–93.8 vs. 100) using both registration pathways. To conclude, the choice of an intermediate registration pathway does not significantly affect registration performance, analysis methods with high spatial resolution are preferable and PSMA-PET outperformed mpMRI in terms of sensitivity in our cohort. |
| format |
article |
| author |
Constantinos Zamboglou Maria Kramer Selina Kiefer Peter Bronsert Lara Ceci August Sigle Wolfgang Schultze-Seemann Cordula A. Jilg Tanja Sprave Thomas F. Fassbender Nils H. Nicolay Juri Ruf Matthias Benndorf Anca L. Grosu Simon K. B. Spohn |
| author_facet |
Constantinos Zamboglou Maria Kramer Selina Kiefer Peter Bronsert Lara Ceci August Sigle Wolfgang Schultze-Seemann Cordula A. Jilg Tanja Sprave Thomas F. Fassbender Nils H. Nicolay Juri Ruf Matthias Benndorf Anca L. Grosu Simon K. B. Spohn |
| author_sort |
Constantinos Zamboglou |
| title |
The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| title_short |
The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| title_full |
The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| title_fullStr |
The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| title_full_unstemmed |
The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| title_sort |
impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d335af9679c14ca7889336d2160d5cae |
| work_keys_str_mv |
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