Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria

The double-strand breaks generated by CRISPR-Cas systems are the target of multiple DNA repair pathways. Here the authors find incompatibility between NHEJ and type II-A CRISPR-Cas systems due to Csn2 mediated inhibition of end-joining.

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Detalles Bibliográficos
Autores principales: Aude Bernheim, Alicia Calvo-Villamañán, Clovis Basier, Lun Cui, Eduardo P. C. Rocha, Marie Touchon, David Bikard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/d335f034b2614a128c2753ae094ff372
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