Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms

Abstract Military and law enforcement breachers are exposed to many low-level blasts during their training and occupational experiences in which they detonate explosives to force entry into secured structures. There is a concern that exposure to these repetitive blast events in career breachers coul...

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Autores principales:	Katie A. Edwards, Kisha Greer, Jacqueline Leete, Chen Lai, Christina Devoto, Bao-Xi Qu, Angela M. Yarnell, Elena Polejaeva, Kristine C. Dell, Matthew L. LoPresti, Peter Walker, Eric M. Wassermann, Walter Carr, James R. Stone, Stephen T. Ahlers, Rany Vorn, Carina Martin, Jessica M. Gill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d3388e7dda954bec80a3bf5137e5a329
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spelling	oai:doaj.org-article:d3388e7dda954bec80a3bf5137e5a3292021-12-02T17:37:40ZNeuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms10.1038/s41598-021-97913-02045-2322https://doaj.org/article/d3388e7dda954bec80a3bf5137e5a3292021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97913-0https://doaj.org/toc/2045-2322Abstract Military and law enforcement breachers are exposed to many low-level blasts during their training and occupational experiences in which they detonate explosives to force entry into secured structures. There is a concern that exposure to these repetitive blast events in career breachers could result in cumulative neurological effects. This study aimed to determine concentrations of neurofilament light (NF-L), tau, and amyloid-beta 42 (Aβ42) in serum and in neuronal-derived extracellular vesicles (EVs) in an experienced breacher population, and to examine biomarker associations with neurobehavioral symptoms. Thirty-four participants enrolled in the study: 20 experienced breachers and 14 matched military or civilian law enforcement controls. EV tau concentrations were significantly elevated in experienced breachers (0.3301 ± 0.5225) compared to controls (−0.4279 ± 0.7557; F = 10.43, p = 0.003). No statistically significant changes were observed in EV levels of NF-L or Aβ42 or in serum levels of NF-L, tau, or Aβ42 (p’s > 0.05). Elevated EV tau concentrations correlated with increased Neurobehavioral Symptom Inventory (NSI) score in experienced breachers (r = 0.596, p = 0.015) and predicted higher NSI score (F(1,14) = 7.702, p = 0.015, R 2 = 0.355). These findings show that neuronal-derived EV concentrations of tau are significantly elevated and associated with neurobehavioral symptoms in this sample of experienced breachers who have a history of many low-level blast exposures.Katie A. EdwardsKisha GreerJacqueline LeeteChen LaiChristina DevotoBao-Xi QuAngela M. YarnellElena PolejaevaKristine C. DellMatthew L. LoPrestiPeter WalkerEric M. WassermannWalter CarrJames R. StoneStephen T. AhlersRany VornCarina MartinJessica M. GillNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katie A. Edwards Kisha Greer Jacqueline Leete Chen Lai Christina Devoto Bao-Xi Qu Angela M. Yarnell Elena Polejaeva Kristine C. Dell Matthew L. LoPresti Peter Walker Eric M. Wassermann Walter Carr James R. Stone Stephen T. Ahlers Rany Vorn Carina Martin Jessica M. Gill Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
description	Abstract Military and law enforcement breachers are exposed to many low-level blasts during their training and occupational experiences in which they detonate explosives to force entry into secured structures. There is a concern that exposure to these repetitive blast events in career breachers could result in cumulative neurological effects. This study aimed to determine concentrations of neurofilament light (NF-L), tau, and amyloid-beta 42 (Aβ42) in serum and in neuronal-derived extracellular vesicles (EVs) in an experienced breacher population, and to examine biomarker associations with neurobehavioral symptoms. Thirty-four participants enrolled in the study: 20 experienced breachers and 14 matched military or civilian law enforcement controls. EV tau concentrations were significantly elevated in experienced breachers (0.3301 ± 0.5225) compared to controls (−0.4279 ± 0.7557; F = 10.43, p = 0.003). No statistically significant changes were observed in EV levels of NF-L or Aβ42 or in serum levels of NF-L, tau, or Aβ42 (p’s > 0.05). Elevated EV tau concentrations correlated with increased Neurobehavioral Symptom Inventory (NSI) score in experienced breachers (r = 0.596, p = 0.015) and predicted higher NSI score (F(1,14) = 7.702, p = 0.015, R 2 = 0.355). These findings show that neuronal-derived EV concentrations of tau are significantly elevated and associated with neurobehavioral symptoms in this sample of experienced breachers who have a history of many low-level blast exposures.
format	article
author	Katie A. Edwards Kisha Greer Jacqueline Leete Chen Lai Christina Devoto Bao-Xi Qu Angela M. Yarnell Elena Polejaeva Kristine C. Dell Matthew L. LoPresti Peter Walker Eric M. Wassermann Walter Carr James R. Stone Stephen T. Ahlers Rany Vorn Carina Martin Jessica M. Gill
author_facet	Katie A. Edwards Kisha Greer Jacqueline Leete Chen Lai Christina Devoto Bao-Xi Qu Angela M. Yarnell Elena Polejaeva Kristine C. Dell Matthew L. LoPresti Peter Walker Eric M. Wassermann Walter Carr James R. Stone Stephen T. Ahlers Rany Vorn Carina Martin Jessica M. Gill
author_sort	Katie A. Edwards
title	Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
title_short	Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
title_full	Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
title_fullStr	Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
title_full_unstemmed	Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
title_sort	neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d3388e7dda954bec80a3bf5137e5a329
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Neuronally-derived tau is increased in experienced breachers and is associated with neurobehavioral symptoms

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